| Class 1Class 1 U.S. senators belong to the electoral cycle that has recently been contested in2012,2010 (special election),2018, and2024. The next election will be in2030. | C | Class 2Class 2 U.S. senators belong to the electoral cycle that has recently been contested in2008,2013 (special election),2014, and2020. The next election will be in2026. |
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| # | Senator | Party | Dates in office | Electoral history | T | T | Electoral history | Dates in office | Party | Senator | # |
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| 1 |  Tristram Dalton (Newburyport) | Pro- Admin. | Mar 4, 1789 – Mar 3, 1791 | Elected in 1788.Lost re-election. | 1 | 1st | 1 | Elected in 1788. | Mar 4, 1789 – Jun 1, 1796 | Pro- Admin. |  Caleb Strong (Northampton) | 1 |
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| 2 |  George Cabot (Beverly) | Pro- Admin. | Mar 4, 1791 – Jun 9, 1796 | Elected in 1790.Resigned. | 2 | 2nd |
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| 3rd | 2 | Re-elected in 1793.Resigned. |
| Federalist | 4th | Federalist |
| Vacant | Jun 9, 1796 – Jun 11, 1796 | Vacant | Vacant | Jun 1, 1796 – Jun 11, 1796 | Vacant |
| 3 |  Benjamin Goodhue (Salem) | Federalist | Jun 11, 1796 – Nov 8, 1800 | Elected to finish Cabot's term. | Elected to finish Strong's term.Retired to run for the U.S. House of Representatives. | Jun 11, 1796 – Mar 3, 1799 | Federalist |  Theodore Sedgwick (Great Barrington) | 2 |
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| Also elected to full term in 1796.Resigned. | 3 | 5th |
| 6th | 3 | Elected in 1798.[7]Resigned to becomeU.S. Secretary of War. | Mar 4, 1799 – May 30, 1800 | Federalist |  Samuel Dexter (Lunenburg) | 3 |
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| Vacant | May 31, 1800 – Jun 5, 1800 | Vacant |
| Elected to finish Dexter's term.[8]Resigned. | Jun 6, 1800 – Mar 3, 1803 | Federalist |  Dwight Foster (Brookfield) | 4 |
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| Vacant | Nov 8, 1800 – Nov 14, 1800 | Vacant |
| 4 |  Jonathan Mason (Boston) | Federalist | Nov 14, 1800 – Mar 3, 1803 | Elected to finish Goodhue's term. |
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| 7th |
| Vacant | Mar 2, 1803 – Mar 3, 1803 | Vacant |
| 5 |  John Quincy Adams (Quincy) | Federalist | Mar 4, 1803 – Jun 8, 1808 | Elected in 1803.[9]Resigned, having lost re-election to the next term. | 4 | 8th | Elected to finish Dexter's term. | Mar 4, 1803 – Mar 3, 1811 | Federalist |  Timothy Pickering (Salem) | 5 |
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| 9th | 4 | Re-elected in 1805.[10]Lost re-election. |
| 10th |
| 6 |  James Lloyd (Boston) | Federalist | Jun 9, 1808 – May 1, 1813 | Elected to finish Adams's term, having already been elected to the next term. |
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| Elected in 1808.[11]Resigned. | 5 | 11th |
| 12th | 5 | State Senate failed to elect. | Mar 4, 1811 – Jun 28, 1811 | Vacant |
| Elected in 1811, to finish the vacant term.Retired or lost re-election. | Jun 29, 1811 – Mar 3, 1817 | Democratic- Republican |  Joseph Bradley Varnum (Dracut) | 6 |
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| 13th |
| Vacant | May 1, 1813 – May 5, 1813 | Vacant |
| 7 |  Christopher Gore (Waltham) | Federalist | May 5, 1813 – May 30, 1816 | Appointed to finish Lloyd's term. |
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| Elected to full term in 1815.Resigned. | 6 | 14th |
| Vacant | May 31, 1816 – Jun 11, 1816 | Vacant |
| 8 | Eli P. Ashmun (Northampton) | Federalist | Jun 12, 1816 – May 10, 1818 | Elected to finish Gore's term.Resigned. |
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| 15th | 6 | Elected in 1816.Resigned to run forMayor of Boston. | Mar 4, 1817 – May 30, 1822 | Federalist |  Harrison Gray Otis (Boston) | 7 |
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| Vacant | May 11, 1818 – Jun 4, 1818 | Vacant |
| 9 |  Prentiss Mellen (Portland)[a] | Federalist | Jun 5, 1818 – May 15, 1820 | Elected to finish Gore's term.Resigned to becomeChief Justice of Maine. |
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| 16th |
| Vacant | May 16, 1820 – Jun 12, 1820 | Vacant |
| 10 |  Elijah H. Mills (Northampton) | Federalist | Jun 12, 1820 – Mar 3, 1827 | Elected to finish Gore's term. |
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| Re-elected in 1820.Lost re-election in 1826. | 7 | 17th |
| Vacant | May 30, 1822 – Jun 5, 1822 | Vacant |
| Elected to finish Otis's term. | Jun 5, 1822 – May 23, 1826 | Federalist |  James Lloyd (Boston) | 8 |
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| 18th | 7 | Re-elected in 1822.Resigned. |
National Republican | 19th | National Republican |
| Vacant | May 23, 1826 – May 31, 1826 | Vacant |
| Elected to finish Lloyd's term. | May 31, 1826 – Mar 3, 1835 | National Republican |  Nathaniel Silsbee (Salem) | 9 |
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| Vacant | Mar 4, 1827 – Jun 8, 1827 | Vacant | 8 | 20th |
| 11 |  Daniel Webster (Marshfield) | National Republican | Jun 8, 1827 – Feb 22, 1841 | Elected late in 1827. |
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| 21st | 8 | Re-elected in 1828.Retired. |
| 22nd |
| Re-elected in 1833. | 9 | 23rd |
| 24th | 9 | Elected in 1835.Resigned to becomeGovernor of Massachusetts. | Mar 4, 1835 – Jan 5, 1841 | National Republican |  John Davis (Worcester) | 10 |
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| Whig | 25th | Whig |
| Re-elected in 1839.Resigned to becomeU.S. Secretary of State. | 10 | 26th |
| Vacant | Jan 5, 1841 – Jan 13, 1841 | Vacant |
| Elected to finish Davis's term. | Jan 13, 1841 – Mar 16, 1845 | Whig |  Isaac C. Bates (Northampton) | 11 |
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| 12 |  Rufus Choate (Boston) | Whig | Feb 23, 1841 – Mar 3, 1845 | Elected to finish Webster's term.Retired. |
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| 27th | 10 | Elected to full term in 1841.Died. |
| 28th |
| 13 |  Daniel Webster (Marshfield) | Whig | Mar 4, 1845 – Jul 22, 1850 | Elected in 1845.Resigned to becomeU.S. Secretary of State again. | 11 | 29th |
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| Vacant | Mar 16, 1845 – Mar 24, 1845 | Vacant |
| Elected to finish Bates's term. | Mar 24, 1845 – Mar 3, 1853 | Whig |  John Davis (Worcester) | 12 |
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| 30th | 11 | Re-elected in 1847.Retired. |
| 31st |
| Vacant | Jul 23, 1850 – Jul 30, 1850 | Vacant |
| 14 |  Robert C. Winthrop (Boston) | Whig | Jul 30, 1850 – Feb 1, 1851 | Appointed to continue Webster's term.Lost election to finish Webster's term. |
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| 15 |  Robert Rantoul Jr. (Beverly) | Democratic | Feb 1, 1851 – Mar 3, 1851 | Elected to finish Webster's term.Retired. |
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| Vacant | Mar 4, 1851 – Apr 24, 1851 | Elected late after the state legislature deadlocked onDaniel Webster's successor | 12 | 32nd |
| 16 |  Charles Sumner (Boston) | Free Soil | Apr 24, 1851 – Mar 11, 1874 |
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| 33rd | 12 | Elected in 1853.Resigned. | Mar 4, 1853 – Jun 1, 1854 | Whig |  Edward Everett (Boston) | 13 |
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| Vacant | Jun 1, 1854 – Jun 3, 1854 | Vacant |
| Appointed to continue Everett's term.Successor was elected. | Jun 3, 1854 – Jan 31, 1855 | Whig |  Julius Rockwell (Pittsfield) | 14 |
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| Elected to finish Everett's term. | Jan 31, 1855 – Mar 3, 1873 | Know Nothing |  Henry Wilson (Natick) | 15 |
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| 34th | Republican |
| Republican | Re-elected in 1857. | 13 | 35th |
| 36th | 13 | Re-elected in 1859. |
| 37th |
| Re-elected in 1863. | 14 | 38th |
| 39th | 14 | Re-elected in 1865. |
| 40th |
| Re-elected in 1869.Died. | 15 | 41st |
| 42nd | 15 | Re-elected in 1871.Resigned to become theVice President of the United States. |
| Liberal Republican | 43rd | Vacant | Mar 3, 1873 – Mar 17, 1873 | Vacant |
| Elected to finish Wilson's term.Lost renomination. | Mar 17, 1873 – Mar 3, 1877 | Republican |  George S. Boutwell (Groton) | 16 |
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| Vacant | Mar 12, 1874 – Apr 16, 1874 | Vacant |
| 17 |  William B. Washburn (Greenfield) | Republican | Apr 17, 1874 – Mar 3, 1875 | Elected to finish Sumner's term.Retired. |
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| 18 |  Henry L. Dawes (Pittsfield) | Republican | Mar 4, 1875 – Mar 3, 1893 | Elected in 1875. | 16 | 44th |
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| 45th | 16 | Elected in 1877. | Mar 4, 1877 – Sep 30, 1904 | Republican |  George F. Hoar (Worcester) | 17 |
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| 46th |
| Re-elected in 1881. | 17 | 47th |
| 48th | 17 | Re-elected in 1883. |
| 49th |
| Re-elected in 1887.Retired. | 18 | 50th |
| 51st | 18 | Re-elected in 1889. |
| 52nd |
| 19 |  Henry Cabot Lodge (Boston) | Republican | Mar 4, 1893 – Nov 9, 1924 | Elected in 1893. | 19 | 53rd |
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| 54th | 19 | Re-elected in 1895. |
| 55th |
| Re-elected in 1899. | 20 | 56th |
| 57th | 20 | Re-elected in 1901.Died. |
| 58th |
| Vacant | Sep 30, 1904 – Oct 12, 1904 | Vacant |
| Appointed to continue Hoar's term.Elected to finish Hoar's term.[12] | Oct 12, 1904 – Mar 3, 1913 | Republican |  Winthrop M. Crane (Dalton) | 18 |
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| Re-elected in 1905.[12] | 21 | 59th |
| 60th | 21 | Re-elected in 1907.Retired. |
| 61st |
| Re-elected in 1911. | 22 | 62nd |
| 63rd | 22 | Elected in 1913.Lost re-election. | Mar 4, 1913 – Mar 3, 1919 | Republican |  John W. Weeks (Newton) | 19 |
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| 64th |
| Re-elected in 1916. | 23 | 65th |
| 66th | 23 | Elected in 1918.Lost re-election. | Mar 4, 1919 – Mar 3, 1925 | Democratic |  David I. Walsh (Boston) | 20 |
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| 67th |
| Re-elected in 1922.Died. | 24 | 68th |
| Vacant | Nov 9, 1924 – Nov 13, 1924 | Vacant |
| 20 |  William M. Butler (Boston) | Republican | Nov 13, 1924 – Dec 6, 1926 | Appointed to continue Lodge's term.Lost election to finish Lodge's term. |
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| 69th | 24 | Elected in 1924.Retired. | Mar 4, 1925 – Mar 3, 1931 | Republican |  Frederick H. Gillett (Springfield) | 21 |
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| 21 |  David I. Walsh (Boston) | Democratic | Dec 6, 1926 – Jan 3, 1947 | Elected to finish Lodge's term. |
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| 70th |
| Re-elected in 1928. | 25 | 71st |
| 72nd | 25 | Elected in 1930.Retired. | Mar 4, 1931 – Jan 3, 1937 | Democratic |  Marcus A. Coolidge (Fitchburg) | 22 |
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| 73rd |
| Re-elected in 1934. | 26 | 74th |
| 75th | 26 | Elected in 1936. | Jan 3, 1937 – Feb 3, 1944 | Republican |  Henry Cabot Lodge Jr. (Beverly) | 23 |
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| 76th |
| Re-elected in 1940.Lost re-election. | 27 | 77th |
| 78th | 27 | Re-elected in 1942.Resigned to return to active duty in theU.S. Army. |
| Vacant | Feb 4, 1944 – Feb 7, 1944 | Vacant |
| Appointed to continue Lodge's term.Did not run for election to finish the term. | Feb 8, 1944 – Dec 19, 1944 | Republican |  Sinclair Weeks (Newton) | 24 |
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| Elected to finish Lodge's term.Didn't take seat until Jan 4, 1945 in order to remainGovernor of Massachusetts. | Dec 19, 1944 – Jan 3, 1967 | Republican |  Leverett Saltonstall (Dover) | 25 |
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| 79th |
| 22 |  Henry Cabot Lodge Jr. (Beverly) | Republican | Jan 3, 1947 – Jan 3, 1953 | Elected in 1946.Lost re-election. | 28 | 80th |
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| 81st | 28 | Re-elected in 1948. |
| 82nd |
| 23 |  John F. Kennedy (Boston) | Democratic | Jan 3, 1953 – Dec 22, 1960 | Elected in 1952. | 29 | 83rd |
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| 84th | 29 | Re-elected in 1954. |
| 85th |
| Re-elected in 1958.Resigned to becomeU.S. President. | 30 | 86th |
| Vacant | Dec 22, 1960 – Dec 27, 1960 | Vacant |
| 24 |  Benjamin Smith (Gloucester) | Democratic | Dec 27, 1960 – Nov 7, 1962 | Appointed to continue John Kennedy's term.Did not run for election to finish the term. |
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| 87th | 30 | Re-elected in 1960.Retired. |
| 25 |  Ted Kennedy (Hyannis Port) | Democratic | Nov 7, 1962 – Aug 25, 2009 | Elected to finish his brother's term. |
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| 88th |
| Re-elected in 1964. | 31 | 89th |
| 90th | 31 | Elected in 1966. | Jan 3, 1967 – Jan 3, 1979 | Republican |  Edward Brooke (Newton) | 26 |
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| 91st |
| Re-elected in 1970. | 32 | 92nd |
| 93rd | 32 | Re-elected in 1972.Lost re-election. |
| 94th |
| Re-elected in 1976. | 33 | 95th |
| 96th | 33 | Elected in 1978.Retired and resigned early to give successor preferential seniority. | Jan 3, 1979 – Jan 2, 1985 | Democratic |  Paul Tsongas (Lowell) | 27 |
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| 97th |
| Re-elected in 1982. | 34 | 98th |
| Appointed to finish Tsongas's term, having already been elected to the next term. | Jan 2, 1985 – Feb 1, 2013 | Democratic |  John Kerry (Boston) | 28 |
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| 99th | 34 | Elected in 1984. |
| 100th |
| Re-elected in 1988. | 35 | 101st |
| 102nd | 35 | Re-elected in 1990. |
| 103rd |
| Re-elected in 1994. | 36 | 104th |
| 105th | 36 | Re-elected in 1996. |
| 106th |
| Re-elected in 2000. | 37 | 107th |
| 108th | 37 | Re-elected in 2002. |
| 109th |
| Re-elected in 2006.Died. | 38 | 110th |
| 111th | 38 | Re-elected in 2008.Resigned to becomeU.S. Secretary of State. |
| Vacant | Aug 25, 2009 – Sep 24, 2009 | Vacant |
| 26 |  Paul G. Kirk (Marstons Mills) | Democratic | Sep 24, 2009 – Feb 4, 2010 | Appointed to continue Ted Kennedy's term.Did not run for election to finish the term.[13] |
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| 27 |  Scott Brown (Wrentham) | Republican | Feb 4, 2010 – Jan 3, 2013 | Elected to finish Ted Kennedy's term.Lost re-election. |
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| 112th |
| 28 |  Elizabeth Warren (Cambridge) | Democratic | Jan 3, 2013 – present | Elected in 2012. | 39 | 113th |
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| Appointed to continue Kerry's term.Did not run for election to finish the term.[14] | Feb 1, 2013 – Jul 15, 2013 | Democratic |  Mo Cowan (Westwood) | 29 |
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| Elected to finish Kerry's term. | Jul 16, 2013 – present | Democratic |  Ed Markey (Malden) | 30 |
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| 114th | 39 | Re-elected in 2014. |
| 115th |
| Re-elected in 2018. | 40 | 116th |
| 117th | 40 | Re-elected in 2020. |
| 118th |
| Re-elected in 2024. | 41 | 119th |
| 120th | 41 | To be determined in the2026 election. |
| # | Senator | Party | Years in office | Electoral history | T | C | T | Electoral history | Years in office | Party | Senator | # |
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| Class 1 | Class 2 |
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