| Class 1Class 1 U.S. senators belong to the electoral cycle that has recently been contested in2006,2012,2018, and2024. The next election will be in 2030. | C | Class 3Class 3 U.S. senators belong to the electoral cycle that has recently been contested in2004,2010,2016, and2022. The next election will be in2028. |
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| # | Senator | Party | Dates in office | Electoral history | T | T | Electoral history | Dates in office | Party | Senator | # |
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| 1 |  Charles Carroll | Pro- Admin. | Mar 4, 1789 – Nov 30, 1792 | Elected in 1788. | 1 | 1st | 1 | Elected in 1788. | Mar 4, 1789 – Dec 10, 1797 | Pro- Admin. | John Henry | 1 |
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| Re-elected in 1791.Resigned to remain in theMaryland Senate. | 2 | 2nd |
| Vacant | Nov 30, 1792 – Jan 10, 1793 | |
| 2 |  Richard Potts | Pro- Admin. | Jan 10, 1793 – Oct 24, 1796 | Elected to finish Carroll's term.Resigned. |
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| 3rd |
| 4th | 2 | Re-elected in 1795.Resigned to becomeGovernor of Maryland. |
| Vacant | Oct 24, 1796 – Nov 30, 1796 | |
| 3 |  John Eager Howard | Federalist | Nov 30, 1796 – Mar 3, 1803 | Elected to finish Carroll's term. |
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| Re-elected in 1796.Lost re-election. | 3 | 5th |
| Elected to finish Henry's term.Resigned. | Dec 11, 1797 – Dec 1, 1800 | Federalist | James Lloyd | 2 |
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| 6th |
| | Dec 1, 1800 – Dec 12, 1800 | Vacant |
| Elected to finish Henry's term. | Dec 12, 1800 – Nov 19, 1801 | Federalist |  William Hindman | 3 |
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| 7th | 3 | Appointed to fill the vacancy after the Legislature failed to elect.Retired when successor elected. |
| Elected to finish term.Resigned to becomeGovernor of Maryland. | Nov 19, 1801 – Nov 12, 1806 | Democratic- Republican |  Robert Wright | 4 |
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| 4 |  Samuel Smith | Democratic- Republican | Mar 4, 1803 – Mar 3, 1815 | Elected in 1802.[3] | 4 | 8th |
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| 9th |
| | Nov 12, 1806 – Nov 25, 1806 | Vacant |
| Elected to finish Wright's term. | Nov 25, 1806 – Mar 3, 1813 | Democratic- Republican |  Philip Reed | 5 |
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| 10th | 4 | Re-elected in 1806. |
| Re-elected in 1809.[4][data missing] | 5 | 11th |
| 12th |
| 13th | 5 | Legislature failed to elect. | Mar 3, 1813 – May 21, 1813 | Vacant |
| Elected in 1813 to finish term.[data missing] | May 21, 1813 – Mar 3, 1819 | Federalist | Robert Henry Goldsborough | 6 |
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| Vacant | Mar 4, 1815 – Jan 29, 1816 | Legislature failed to elect | 6 | 14th |
| 5 |  Robert Goodloe Harper | Federalist | Jan 29, 1816 – Dec 6, 1816 | Elected to finish term.Resigned. |
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| Vacant | Dec 6, 1816 – Dec 20, 1816 | |
| 6 |  Alexander Hanson | Federalist | Dec 20, 1816 – Apr 23, 1819 | Elected to finish the vacant term that happened from 1815 to 1816.Died. |
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| 15th |
| 16th | 6 | Legislature did not elect until after the term began. | Mar 4, 1819 – Dec 20, 1819 | Vacant |
| Vacant | Apr 23, 1819 – Dec 21, 1819 | |
| 7 |  William Pinkney | Democratic- Republican | Dec 20, 1819 – Feb 25, 1822 | Elected in 1819 to finish the vacant term that happened from 1815 to 1816. | Elected late in 1819. | Dec 21, 1819 – Jan 14, 1826 | Democratic- Republican |  Edward Lloyd | 7 |
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| Re-elected in 1821.Died. | 7 | 17th |
| Vacant | Feb 25, 1822 – Dec 17, 1822 | |
| 8 |  Samuel Smith | Democratic- Republican | Dec 17, 1822 – Mar 3, 1833 | Elected to finish Pinkney's term. |
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| 18th |
| Jacksonian | 19th | 7 | Re-elected in 1825.Resigned. | Jacksonian |
| | Jan 14, 1826 – Jan 24, 1826 | Vacant |
| Elected to finish Lloyd's term. | Jan 24, 1826 – Dec 20, 1834 | National Republican |  Ezekiel F. Chambers | 8 |
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| Re-elected in 1827. | 8 | 20th |
| 21st |
| 22nd | 8 | Re-elected in 1831.Resigned to become judge of theMaryland Court of Appeals. |
| 9 |  Joseph Kent | National Republican | Mar 4, 1833 – Nov 24, 1837 | Elected in 1833.Died. | 9 | 23rd |
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| | Dec 20, 1834 – Jan 13, 1835 | Vacant |
| Elected to finish Chambers's term.Died. | Jan 13, 1835 – Oct 5, 1836 | National Republican | Robert Henry Goldsborough | 9 |
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| 24th |
| | Oct 5, 1836 – Dec 31, 1836 | Vacant |
| Elected to finish Chambers's term. | Dec 31, 1836 – Oct 24, 1840 | National Republican | John S. Spence | 10 |
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| Whig | 25th | 9 | Re-elected in 1837.Died. | Whig |
| Vacant | Nov 24, 1837 – Jan 4, 1838 | |
| 10 | William Duhurst Merrick | Whig | Jan 4, 1838 – Mar 3, 1845 | Elected to finish Kent's term. |
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| Re-elected in 1839.[data missing] | 10 | 26th |
| | Oct 24, 1840 – Jan 5, 1841 | Vacant |
| Elected to finish Spence's term.[data missing] | Jan 5, 1841 – Mar 3, 1843 | Whig |  John Leeds Kerr | 11 |
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| 27th |
| 28th | 10 | Elected in 1843. | Mar 4, 1843 – Dec 20, 1862 | Whig |  James Pearce | 12 |
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| 11 |  Reverdy Johnson | Whig | Mar 4, 1845 – Mar 7, 1849 | Election year unknown.Resigned to becomeU.S. Attorney General. | 11 | 29th |
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| 30th |
| 31st | 11 | Re-elected in 1849. |
| Vacant | Mar 7, 1849 – Dec 6, 1849 | |
| 12 |  David Stewart | Democratic | Dec 6, 1849 – Jan 12, 1850 | Appointed to continue Johnson's term.Retired when successor elected. |
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| 13 |  Thomas Pratt | Whig | Jan 12, 1850 – Mar 3, 1857 | Elected to finish Johnson's term. |
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| Re-elected in 1851. | 12 | 32nd |
| 33rd |
| 34th | 12 | Re-elected in 1855. |
| 14 |  Anthony Kennedy | American | Mar 4, 1857 – Mar 3, 1863 | Election year unknown. [data missing] | 13 | 35th | Democratic |
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| 36th |
| Union | 37th | 13 | Re-elected in 1860.Died. |
| | Dec 20, 1862 – Dec 29, 1862 | Vacant |
| Appointed to continue Pearce's term.Elected in 1864 to finish Pearce's term.Died. | Dec 29, 1862 – Feb 14, 1865 | Union |  Thomas Holliday Hicks | 13 |
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| 15 |  Reverdy Johnson | Union | Mar 4, 1863 – Jul 10, 1868 | Election year unknown.Resigned to becomeU.S. Ambassador to the United Kingdom of Great Britain and Ireland. | 14 | 38th |
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| | Feb 14, 1865 – Mar 9, 1865 | Vacant |
| Democratic | 39th |
| Elected to finish Pearce's term.[data missing] | Mar 9, 1865 – Mar 3, 1867 | Unconditional Union |  John Creswell | 14 |
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| 40th | 14 | Philip F. Thomas (D) was elected but failed to qualify due to his support for the Confederacy. | Mar 4, 1867 – Mar 7, 1868 | Vacant |
| Elected to finish Thomas's term.[data missing] | Mar 7, 1868 – Mar 3, 1873 | Democratic |  George Vickers | 15 |
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| Vacant | Jul 10, 1868 – Jul 13, 1868 | |
| 16 |  William Whyte | Democratic | Jul 13, 1868 – Mar 3, 1869 | Appointed to finish Johnson's term.Retired. |
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| 17 |  William T. Hamilton | Democratic | Mar 4, 1869 – Mar 3, 1875 | Election year unknown.Retired to run for governor. | 15 | 41st |
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| 42nd |
| 43rd | 15 | Election year unknown.[data missing] | Mar 4, 1873 – Mar 3, 1879 | Democratic |  George R. Dennis | 16 |
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| 18 |  William Whyte | Democratic | Mar 4, 1875 – Mar 3, 1881 | Elected in 1874.Retired. | 16 | 44th |
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| 45th |
| 46th | 16 | Elected in 1878.[5][data missing] | Mar 4, 1879 – Mar 3, 1885 | Democratic |  James Black Groome | 17 |
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| 19 |  Arthur P. Gorman | Democratic | Mar 4, 1881 – Mar 3, 1899 | Elected in 1880. | 17 | 47th |
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| 48th |
| 49th | 17 | Elected in 1884.Re-elected in 1890.Died. | Mar 4, 1885 – Feb 24, 1891 | Democratic |  Ephraim Wilson | 18 |
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| Re-elected in 1886. | 18 | 50th |
| 51st |
| | Feb 24, 1891 – Nov 19, 1891 | Vacant |
| 52nd | 18 |
| Appointed to continue Wilson's term.Elected in 1892 to finish Wilson's term.[6]Unknown if retired or lost re-election. | Nov 19, 1891 – Mar 3, 1897 | Democratic |  Charles H. Gibson | 19 |
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| Elected in 1892.Lost re-election. | 19 | 53rd |
| 54th |
| 55th | 19 | Elected in 1896.[7]Retired. | Mar 4, 1897 – Mar 3, 1903 | Republican |  George L. Wellington | 20 |
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| 20 |  Louis E. McComas | Republican | Mar 4, 1899 – Mar 3, 1905 | Elected in 1898.Retired to become judge of theU.S. Court of Appeals. | 20 | 56th |
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| 57th |
| 58th | 20 | Elected in 1902.[8]Died. | Mar 4, 1903 – Jun 4, 1906 | Democratic |  Arthur P. Gorman | 21 |
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| 21 |  Isidor Rayner | Democratic | Mar 4, 1905 – Nov 25, 1912 | Elected in 1904. | 21 | 59th |
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| | Jun 4, 1906 – Jun 8, 1906 | Vacant |
| Appointed to continue Gorman's term.Elected in 1908 to finish Gorman's term.[6]Died. | Jun 8, 1906 – Mar 17, 1908 | Democratic |  William Whyte | 22 |
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| 60th |
| | Mar 17, 1908 – Mar 25, 1908 | Vacant |
| Elected to finish Gorman's term, having already been elected to the next term. | Mar 25, 1908 – Mar 3, 1921 | Democratic |  John Walter Smith | 23 |
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| 61st | 21 | Elected in 1908. |
| Re-elected in 1910.Died. | 22 | 62nd |
| Vacant | Nov 25, 1912 – Nov 29, 1912 | |
| 22 |  William P. Jackson | Republican | Nov 29, 1912 – Jan 28, 1914 | Appointed to continue Rayner's term.Retired when successor elected. |
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| 63rd |
| 23 |  Blair Lee | Democratic | Jan 28, 1914 – Mar 3, 1917 | Elected in 1913 to finish Rayner's term.Lost re-election. |
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| 64th | 22 | Re-elected in 1914.Lost re-election. |
| 24 |  Joseph I. France | Republican | Mar 4, 1917 – Mar 3, 1923 | Elected in 1916.Lost re-election. | 23 | 65th |
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| 66th |
| 67th | 23 | Elected in 1920.Lost re-election. | Mar 4, 1921 – Mar 3, 1927 | Republican |  Ovington Weller | 24 |
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| 25 |  William Cabell Bruce | Democratic | Mar 4, 1923 – Mar 3, 1929 | Elected in 1922.Lost re-election. | 24 | 68th |
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| 69th |
| 70th | 24 | Elected in 1926. | Mar 4, 1927 – Jan 3, 1951 | Democratic |  Millard Tydings | 25 |
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| 26 |  Phillips Lee Goldsborough | Republican | Mar 4, 1929 – Jan 3, 1935 | Elected in 1928.Retired to run for governor. | 25 | 71st |
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| 72nd |
| 73rd | 25 | Re-elected in 1932. |
| 27 |  George L. P. Radcliffe | Democratic | Jan 3, 1935 – Jan 3, 1947 | Elected in 1934. | 26 | 74th |
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| 75th |
| 76th | 26 | Re-elected in 1938. |
| Re-elected in 1940.Lost renomination. | 27 | 77th |
| 78th |
| 79th | 27 | Re-elected in 1944.Lost re-election. |
| 28 |  Herbert O'Conor | Democratic | Jan 3, 1947 – Jan 3, 1953 | Elected in 1946.Retired. | 28 | 80th |
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| 81st |
| 82nd | 28 | Elected in 1950. | Jan 3, 1951 – Jan 3, 1963 | Republican |  John Marshall Butler | 26 |
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| 29 |  J. Glenn Beall | Republican | Jan 3, 1953 – Jan 3, 1965 | Elected in 1952. | 29 | 83rd |
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| 84th |
| 85th | 29 | Re-elected in 1956.Retired. |
| Re-elected in 1958.Lost re-election. | 30 | 86th |
| 87th |
| 88th | 30 | Elected in 1962.Lost re-election. | Jan 3, 1963 – Jan 3, 1969 | Democratic |  Daniel Brewster | 27 |
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| 30 |  Joseph Tydings | Democratic | Jan 3, 1965 – Jan 3, 1971 | Elected in 1964.Lost re-election. | 31 | 89th |
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| 90th |
| 91st | 31 | Elected in 1968. | Jan 3, 1969 – Jan 3, 1987 | Republican |  Charles Mathias | 28 |
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| 31 |  J. Glenn Beall Jr. | Republican | Jan 3, 1971 – Jan 3, 1977 | Elected in 1970.Lost re-election. | 32 | 92nd |
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| 93rd |
| 94th | 32 | Re-elected in 1974. |
| 32 |  Paul Sarbanes | Democratic | Jan 3, 1977 – Jan 3, 2007 | Elected in 1976. | 33 | 95th |
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| 96th |
| 97th | 33 | Re-elected in 1980.Retired. |
| Re-elected in 1982. | 34 | 98th |
| 99th |
| 100th | 34 | Elected in 1986. | Jan 3, 1987 – Jan 3, 2017 | Democratic |  Barbara Mikulski | 29 |
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| Re-elected in 1988. | 35 | 101st |
| 102nd |
| 103rd | 35 | Re-elected in 1992. |
| Re-elected in 1994. | 36 | 104th |
| 105th |
| 106th | 36 | Re-elected in 1998. |
| Re-elected in 2000.Retired. | 37 | 107th |
| 108th |
| 109th | 37 | Re-elected in 2004. |
| 33 |  Ben Cardin | Democratic | Jan 3, 2007 – Jan 3, 2025 | Elected in 2006. | 38 | 110th |
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| 111th |
| 112th | 38 | Re-elected in 2010.Retired. |
| Re-elected in 2012. | 39 | 113th |
| 114th |
| 115th | 39 | Elected in 2016. | Jan 3, 2017 – present | Democratic |  Chris Van Hollen | 30 |
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| Re-elected in 2018.Retired. | 40 | 116th |
| 117th |
| 118th | 40 | Re-elected in 2022. |
| 34 |  Angela Alsobrooks | Democratic | Jan 3, 2025 – present | Elected in 2024. | 41 | 119th |
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| 120th |
| 121st | 41 | To be determined in the 2028 election. |
| To be determined in the 2030 election. | 42 | 122nd |
| # | Senator | Party | Years in office | Electoral history | T | C | T | Electoral history | Years in office | Party | Senator | # |
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| Class 1 | Class 3 |
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