| Name | Nationality | Position | Palermo career | Appearances | Goals | Note |
|---|
| Carlo Radice | Italy | FW | 1929–1933, 1934–1935 | ? | 64 | Most league goals |
| Archimede Valeriani | Italy | GK | 1929–1934 | 152 | 0 | |
| Américo Ruffino | Argentina | FW | 1929–1934 | 135 | 32 | |
| Ettore Banchero | Italy | FW | 1931–1933 | 55 | 21 | |
| Antonio Blasevich | Italy | MF | 1931–1935 | 121 | 17 | |
| Luigi Ziroli | Italy | MF | 1931–1940 | 194 | 9 | |
| Gennaro Santillo | Italy | DF | 1932–1940 | 234 | 5 | |
| Héctor Scarone | Uruguay | MF | 1932–1934 | 56 | 4 | 1930 FIFA World Cup winner |
| Maximiliano Faotto | Uruguay | DF | 1932–1942, 1945–1947 | 129 | 3 | |
| Oliver Icardi | Uruguay | MF | 1935–1937, 1939–1940 | 54 | 24 | |
| Umberto Di Falco | Italy | FW | 1936–1940 | 73 | 26 | |
| Carmelo Di Bella | Italy | MF | 1941–1949 | 111 | 12 | |
| Čestmír Vycpálek | Czechoslovakia | MF | 1947–1952 | 143 | 23 | |
| Aurelio Pavesi De Marco | Italy | FW | 1947–1950 | 59 | 35 | |
| Dante Di Maso | Italy | MF | 1947–1948, 1949–1955 | 164 | 42 | |
| Pietro De Santis | Italy | FW | 1948–1950 | 60 | 20 | |
| Carlo Galli | Italy | FW | 1949–1951 | 45 | 16 | 1954 FIFA World Cup participant |
| Aredio Gimona | Italy | MF | 1949–1953 | 124 | 9 | |
| Gino Giaroli | Italy | DF | 1949–1954 | 151 | 7 | |
| Helge Bronée | Denmark | MF | 1950–1952 | 70 | 22 | |
| Şükrü Gülesin | Turkey | FW | 1950–1951, 1952–1953 | 50 | 20 | |
| Bülent Eken | Turkey | DF | 1951–1952 | 17 | 0 | 1954 FIFA World Cup participant |
| Benigno De Grandi | Italy | DF | 1951–1954, 1955–1956 | 97 | 8 | |
| Enrique Martegani | Argentina | FW | 1952–1955 | 93 | 21 | |
| Enzo Benedetti | Italy | DF | 1955–1965 | 274 | 0 | |
| Walter Gómez | Uruguay | FW | 1956–1958 | 48 | 8 | |
| Santiago Vernazza | Argentina | FW | 1956–1960 | 115 | 51 | |
| Antonio De Bellis | Italy | DF | 1957–1961, 1965–1971 | 258 | 0 | |
| Alberto Malavasi | Italy | MF | 1957–1965 | 248 | 11 | |
| Roberto Anzolin | Italy | GK | 1959–1961 | 71 | 0 | 1966 FIFA World Cup participant |
| Dionisio Arce | Paraguay | FW | 1959–1961 | 27 | 2 | |
| Tarcisio Burgnich | Italy | DF | 1961–1962 | 31 | 1 | 1966,1970,1974 FIFA World Cup participant |
| Rune Börjesson | Sweden | MF | 1961–1962 | 38 | 10 | |
| Carlo Mattrel | Italy | GK | 1961–1962 | 34 | 0 | 1962 FIFA World Cup participant |
| Metin Oktay | Turkey | FW | 1961–1962 | 12 | 3 | |
| José Ferdinando Puglia | Brazil | MF | 1961–1963 | 62 | 13 | |
| Lennart Skoglund | Sweden | MF | 1962–1963 | 6 | 0 | 1950,1958 FIFA World Cup participant |
| Mario Giubertoni | Italy | DF | 1964–1970 | 199 | 2 | |
| Giovanni Ferretti | Italy | GK | 1964–1974 | 166 | 0 | |
| Gaetano Troja | Italy | FW | 1964–1966, 1968–1973 | 172 | 43 | |
| Ignazio Arcoleo | Italy | MF | 1966–1967, 1970–1974, 1978–1980 | 192 | 6 | |
| Silvino Bercellino | Italy | FW | 1966–1972 | 134 | 39 | |
| Franco Landri | Italy | DF | 1966–1973 | 213 | 2 | |
| Romeo Benetti | Italy | MF | 1967–1968 | 35 | 2 | 1974,1978 FIFA World Cup participant |
| Giuseppe Furino | Italy | DF | 1968–1969 | 27 | 1 | 1970 FIFA World Cup participant |
| Sergio Pellizzaro | Italy | FW | 1968–1971 | 85 | 23 | |
| Enzo Ferrari | Italy | FW | 1968–1972 | 126 | 22 | |
| Edoardo Reja | Italy | MF | 1968–1973 | 124 | 1 | |
| Franco Causio | Italy | MF | 1969–1970 | 22 | 3 | 1982 FIFA World Cup winner |
| Spartaco Landini | Italy | DF | 1970–1973 | 97 | 0 | 1966 FIFA World Cup participant |
| Sergio Girardi | Italy | GK | 1970–1974 | 119 | 0 | |
| Sandro Vanello | Italy | MF | 1970–1975 | 153 | 12 | |
| Erminio Favalli | Italy | DF | 1971–1978 | 203 | 6 | |
| Sergio Magistrelli | Italy | FW | 1973–1974, 1976–1978 | 87 | 23 | |
| Antonino Trapani | Italy | GK | 1974–1979 | 119 | 0 | |
| Valerio Majo | Italy | MF | 1974–1978, 1983–1986 | 212 | 12 | |
| Filippo Citterio | Italy | DF | 1975–1979 | 129 | 2 | |
| Lorenzo Frison | Italy | GK | 1975–1981 | 103 | 0 | |
| Mauro Di Cicco | Italy | DF | 1976–1984 | 237 | 0 | |
| Vito Chimenti | Italy | FW | 1977–1979 | 74 | 29 | |
| Gian Piero Gasperini | Italy | MF | 1978–1983 | 128 | 11 | |
| Massimo De Stefanis | Italy | MF | 1979–1984 | 169 | 30 | |
| Giampaolo Montesano | Italy | MF | 1979–1984 | 170 | 21 | |
| Giuseppe Volpecina | Italy | DF | 1980–1984 | 133 | 6 | |
| Gianni De Rosa | Italy | FW | 1981–1983 | 61 | 29 | Serie B topscorer title as a Palermo player |
| Tebaldo Bigliardi | Italy | DF | 1981–1986, 1993–1994 | 144 | 1 | |
| Gianni De Biasi | Italy | MF | 1983–1986 | 105 | 7 | |
| Pietro De Sensi | Italy | DF | 1987–1994 | 201 | 17 | |
| Domenico Di Carlo | Italy | MF | 1987–1990 | 97 | 6 | |
| Roberto Biffi | Italy | DF | 1988–1999 | 319 | 15 | Most league appearances |
| Vincenzo Sicignano | Italy | GK | 1994–2003 | 182 | 0 | |
| Gianluca Berti | Italy | GK | 1995–1996, 2003–2004 | 78 | 0 | |
| Gaetano Vasari | Italy | MF | 1995–1997, 2003–2004 | 95 | 18 | |
| Davide Bombardini | Italy | MF | 1999–2002 | 94 | 15 | |
| Massimiliano Cappioli | Italy | MF | 2000–2002 | 57 | 16 | |
| Christian La Grotteria | Argentina | FW | 2000–2003 | 80 | 17 | |
| Daniele Di Donato | Italy | MF | 2000–2004 | 133 | 4 | |
| Franco Brienza | Italy | FW | 2000–2002, 2003–2008 | 168 | 17 | |
| Mario Santana | Argentina | MF | 2002–2003, 2004–2006 | 91 | 4 | |
| Lamberto Zauli | Italy | FW | 2002–2005 | 69 | 14 | Serie B promotion captain |
| Simone Pepe | Italy | MF | 2003–2004, 2005–2006 | 22 | 1 | 2010 FIFA World Cup participant |
| Eugenio Corini | Italy | MF | 2003–2007 | 129 | 25 | |
| Luca Toni | Italy | FW | 2003–2005 | 80 | 51 | 2006 FIFA World Cup winner; most goals in a season |
| Simone Barone | Italy | MF | 2004–2006 | 71 | 5 | 2006 FIFA World Cup winner |
| Andrea Barzagli | Italy | DF | 2004–2008 | 142 | 4 | 2006 FIFA World Cup winner |
| Giuseppe Biava | Italy | DF | 2004–2008 | 112 | 5 | |
| Fabio Grosso | Italy | DF | 2004–2006 | 90 | 2 | 2006 FIFA World Cup winner |
| Cristian Zaccardo | Italy | DF | 2004–2008 | 142 | 8 | 2006 FIFA World Cup winner |
| Mariano Andújar | Argentina | GK | 2005–2006 | 11 | 0 | 2010 and2014 FIFA World Cup participant |
| Giovanni Tedesco | Italy | MF | 2005–2010 | 78 | 9 | |
| Amauri | Italy | FW | 2006–2008 | 52 | 23 | |
| Alberto Fontana | Italy | GK | 2006–2009 | 66 | 0 | |
| Fábio Simplício | Brazil | MF | 2006–2010 | 129 | 21 | Capped as Palermo player |
| Mark Bresciano | Australia | MF | 2006–2010 | 107 | 12 | 2006,2010 and2014 FIFA World Cup participant |
| Mattia Cassani | Italy | DF | 2006–2011 | 161 | 2 | Most European appearances |
| Salvatore Sirigu | Italy | GK | 2006–2011 | 69 | 0 | 2014 FIFA World Cup participant |
| Cesare Bovo | Italy | DF | 2006–2007, 2008–2011 | 89 | 7 | |
| Fabrizio Miccoli | Italy | FW | 2007–2013 | 165 | 74 | Most Serie A league goals |
| Edinson Cavani | Uruguay | FW | 2007–2010 | 109 | 34 | 2010 and2014 FIFA World Cup participant |
| Marco Amelia | Italy | GK | 2008–2009 | 34 | 0 | 2006 FIFA World Cup winner |
| Simon Kjær | Denmark | DF | 2008–2010 | 62 | 5 | 2010 FIFA World Cup participant |
| Antonio Nocerino | Italy | MF | 2008–2011 | 106 | 6 | |
| Fabio Liverani | Italy | MF | 2008–2011 | 66 | 0 | |
| Federico Balzaretti | Italy | DF | 2008–2012 | 143 | 3 | |
| Dorin Goian | Romania | DF | 2009–2011 | 30 | 1 | |
| Javier Pastore | Argentina | MF | 2009–2011 | 69 | 14 | 2010 FIFA World Cup participant |
| Abel Hernández | Uruguay | FW | 2009–2014 | 111 | 31 | 2014 FIFA World Cup participant |
| Matteo Darmian | Italy | DF | 2010–2011 | 11 | 0 | 2014 FIFA World Cup participant |
| Mauricio Pinilla | Chile | FW | 2010–2012 | 35 | 10 | 2014 FIFA World Cup participant |
| Josip Iličić | Slovenia | MF | 2010–2013 | 98 | 20 | |
| Ezequiel Muñoz | Argentina | DF | 2010–2015 | 131 | 5 | |
| Afriyie Acquah | Ghana | MF | 2011–2013 | 31 | 0 | 2014 FIFA World Cup participant |
| Alexandros Tzorvas | Greece | GK | 2011–2012 | 11 | 0 | 2010 FIFA World Cup participant |
| Eran Zahavi | Israel | MF | 2011–2012 | 23 | 2 | |
| Édgar Barreto | Paraguay | MF | 2011–2015 | 122 | 7 | 2006 and2010 FIFA World Cup participant |
| Steve von Bergen | Switzerland | DF | 2012–2013 | 34 | 1 | 2010 and2014 FIFA World Cup participant |
| Egidio Arévalo Ríos | Uruguay | MF | 2012–2013 | 27 | 2 | 2010 and2014 FIFA World Cup participant |
| Emiliano Viviano | Italy | GK | 2012–2014 | 20 | 0 | |
| Paulo Dybala | Argentina | FW | 2012–2015 | 90 | 21 | 2022 FIFA World Cup winner;2022 Finalissima winner;2021 Copa América winner |
| Franco Vázquez | Italy | MF | 2012–2016 | 105 | 22 | |
| Kyle Lafferty | Northern Ireland | FW | 2013–2014 | 34 | 11 | |
| Andrea Belotti | Italy | FW | 2013–2015 | 62 | 16 | |
| Stefano Sorrentino | Italy | GK | 2013–2016 | 117 | 0 | |
| Enzo Maresca | Italy | MF | 2014–2016 | 47 | 1 | |
| Achraf Lazaar | Morocco | DF | 2014–2016 | 73 | 3 | |
| Giancarlo González | Costa Rica | DF | 2014–2017 | 82 | 4 | 2014 FIFA World Cup participant |
| Robin Quaison | Sweden | MF | 2014–2017 | 66 | 7 | 2015 UEFA European Under-21 Championship winner |
| Ivaylo Chochev | Bulgaria | DF | 2014–2019 | 116 | 12 | |
| Oscar Hiljemark | Sweden | MF | 2015–2017 | 53 | 4 | 2015 UEFA European Under-21 Championship winner |
| Alberto Gilardino | Italy | FW | 2015–2016 | 33 | 10 | 2006 FIFA World Cup winner |
| Alessandro Diamanti | Italy | MF | 2016–2017 | 31 | 1 | |
| Aleksandar Trajkovski | North Macedonia | FW | 2015–2019 | 104 | 16 | |
| Ilija Nestorovski | North Macedonia | FW | 2016–2019 | 94 | 38 | |
| Toni Šunjić | Bosnia and Herzegovina | DF | 2017 | 7 | 0 | 2014 FIFA World Cup participant |
| Matteo Brunori | Italy | FW | 2021– | 66 | 40 | |