| Name | Years | Notes |
|---|
| Fred Haney | 1960–1968 | Became the first General Manager of the team when tapped by owner Gene Autry. Retired in 1968. |
| Dick Walsh | 1968–1971 | Named successor as General Manager by Gene Autry following the retirement of Haney. Walsh was fired by Autry after the 1971 season due to the team failing to meet expectations. |
| Harry Dalton | 1971–1977 | Was hired by Autry away from theBaltimore Orioles. Acquired pitcherNolan Ryan from theNew York Mets. After the 1977 season the Angels released Dalton from his contract. |
| Buzzie Bavasi | 1977–1984 | Hired by Autry, Bavasi took the team to its first two appearances in thepostseason. Retired in 1984. |
| Mike Port | 1984–1991 | |
| Dan O'Brien Sr. | 1991–1993 | |
| Whitey Herzog | 1993–1994 | Former St. Louis Cardinals manager during the 1980s |
| Bill Bavasi | 1994–1999 | Son of former General Manager Buzzie Bavasi. |
| Bill Stoneman | 1999–2007 | Former pitcher, who threw the first no-hitter in Montreal Expos' history; won the World Series as Angels GM in 2002. |
| Tony Reagins | 2007–2011 | Became the first African-American General Manager in club history. |
| Jerry Dipoto | 2011–2015 | Former MLB pitcher (1993–2000). |
| Billy Eppler | 2015–2020 | |
| Perry Minasian | 2020–present | |
