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Linuron

From Wikipedia, the free encyclopedia
Herbicide
Pharmaceutical compound
Linuron
Identifiers
  • N'-(3,4-dichlorophenyl)-N-methoxy-N-methylurea
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
ECHA InfoCard100.005.779Edit this at Wikidata
Chemical and physical data
FormulaC9H10Cl2N2O2
Molar mass249.09 g·mol−1
3D model (JSmol)
Density1.49 g/cm3
Melting point93 to 95 °C (199 to 203 °F)
  • CON(C)C(=O)Nc1ccc(Cl)c(Cl)c1
  • InChI=1S/C9H10Cl2N2O2/c1-13(15-2)9(14)12-6-3-4-7(10)8(11)5-6/h3-5H,1-2H3,(H,12,14)
  • Key:XKJMBINCVNINCA-UHFFFAOYSA-N

Linuron is aphenylureaherbicide[1] that is used to control the growth of grass and weeds for the purpose of supporting the growth ofcrops likesoybeans.[2][3]

Pharmacology

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Mechanism of action

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Linuron acts via inhibition ofphotosystem II, which is necessary forphotosynthetic electron transport inplants.[2][3] Fluometron'sherbicide resistance class isGroup C, (Australia),C2 (global),Group 7, (numeric, i.e. Group 5, due to a merger).[4]

Effects in animals

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Linuron has been found to producereproductivetoxicity in animals by acting as anandrogen receptor (AR)antagonist, and for this reason, is considered to be anendocrine disruptor.[2][5] Consequently, in January 2017, theStanding Committee on Plants, Animals, Food and Feed (SCoPAFF) of the European Commission DG "Health and food safety" decided to not renew its regulatory approval.[6] Sales are expected to cease by June 2017.[6]

See also

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References

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  1. ^Maier-Bode H, Härtel K (1981). "Linuron and monolinuron".Residue Reviews. Reviews of Environmental Contamination and Toxicology. Vol. 77. pp. 1–364.doi:10.1007/978-1-4612-5874-2_1.ISBN 978-1-4612-5876-6.PMID 7017855.
  2. ^abcMercurio S (30 August 2016).Understanding Toxicology. Jones & Bartlett Learning. pp. 705–.ISBN 978-1-284-12761-4.
  3. ^abRoberts TR (1998).Metabolic Pathways of Agrochemicals. Royal Society of Chemistry. pp. 744–.ISBN 978-0-85404-494-8.
  4. ^"Classification of Herbicides According to Site of Action". Retrieved19 July 2025.
  5. ^"Peer review of the pesticide risk assessment of the active substance linuron".EFSA Journal.14 (7). July 2016.doi:10.2903/j.efsa.2016.4518.
  6. ^abCurtis M."Linuron fails to gain renewed approval".fginsight.com. Briefing Media Ltd. Archived fromthe original on 31 October 2021. Retrieved24 May 2017.
Anilides/anilines
Aromaticacids
Arsenicals
HPPD inhbitors
Nitriles
Organophosphorus
Phenoxy
Auxins
ACCase inhibitors
FOP herbicides
DIM herbicides
Protox inhibitors
Nitrophenyl ethers
Pyrimidinediones
Triazolinones
Pyridines
Quaternary
Photosystem I inhibitors
Thiocarbamates
Triazines
cellulose biosynthesis inhibitors
Photosystem II inhibitors
Ureas
Photosystem II inhibitors
ALS inhibitors
Others
Pest control: Urea herbicides
Phenylureas
Ureas
ARTooltip Androgen receptor
Agonists
SARMsTooltip Selective androgen receptor modulator
Antagonists
GPRC6A
Agonists
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