 Top: (R)-(−)-licarbazepine Bottom: (S)-(+)-licarbazepine | |
| Clinical data | |
|---|---|
| ATC code |
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| Pharmacokinetic data | |
| Protein binding | <40% |
| Metabolites | Glucuronides |
| Excretion | Mainlyrenal |
| Identifiers | |
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| CAS Number | |
| PubChemCID | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEMBL | |
| CompTox Dashboard(EPA) | |
| ECHA InfoCard | 100.122.427 |
| Chemical and physical data | |
| Formula | C15H14N2O2 |
| Molar mass | 254.289 g·mol−1 |
| 3D model (JSmol) | |
| Chirality | Racemic mixture |
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Licarbazepine is avoltage-gated sodium channelblocker withanticonvulsant andmood-stabilizing effects that is related tooxcarbazepine.[1] It is anactive metabolite ofoxcarbazepine.[1][2] In addition, anenantiomer of licarbazepine,eslicarbazepine ((S)-(+)-licarbazepine), is an active metabolite ofeslicarbazepine acetate.[1][2] Oxcarbazepine and eslicarbazepine acetate are inactive on their own, and behave instead asprodrugs to licarbazepine and eslicarbazepine, respectively, to produce their therapeutic effects.[1][2]
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