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Levormeloxifene

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Levormeloxifene
Clinical data
Other namesLevomeloxifene; 6720-CDRI; NNC-460020
Identifiers
  • 1-(2-[4-[(3R,4R)-7-Methoxy-2,2-dimethyl-3-phenyl-3,4-dihydro-2H-chromen-4-yl]phenoxy]ethyl)pyrrolidine
CAS Number
PubChemCID
ChemSpider
UNII
ChEMBL
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC30H35NO3
Molar mass457.614 g·mol−1
3D model (JSmol)
  • O(c1ccc(cc1)[C@@H]3c4c(OC([C@H]3c2ccccc2)(C)C)cc(OC)cc4)CCN5CCCC5
  • InChI=1S/C30H35NO3/c1-30(2)29(23-9-5-4-6-10-23)28(26-16-15-25(32-3)21-27(26)34-30)22-11-13-24(14-12-22)33-20-19-31-17-7-8-18-31/h4-6,9-16,21,28-29H,7-8,17-20H2,1-3H3/t28-,29+/m1/s1 checkY
  • Key:XZEUAXYWNKYKPL-WDYNHAJCSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Levormeloxifene (INNTooltip International Nonproprietary Name; developmental code names6720-CDRI,NNC-460020) is aselective estrogen receptor modulator (SERM) which was being developed as an alternative toestrogen replacement therapy for the treatment and prevention ofpostmenopausalbone loss but did not complete development and hence was never marketed.[1] The development was stopped because of a high incidence ofgynecologicalside effects duringclinical trials.[2] Levormeloxifene is thelevorotatoryenantiomer oformeloxifene, which, in contrast, has been marketed, though rather as ahormonal contraceptive.

See also

[edit]

References

[edit]
  1. ^"Levormeloxifene - AdisInsight".
  2. ^Ravn P, Nielsen TF, Christiansen C (2006)."What can be learned from the levormeloxifene experience?".Acta Obstet Gynecol Scand.85 (2):135–42.doi:10.1080/00016340500345691.PMID 16532904.S2CID 12872469.

External links

[edit]
ERTooltip Estrogen receptor
Agonists
Mixed
(SERMsTooltip Selective estrogen receptor modulators)
Antagonists
GPERTooltip G protein-coupled estrogen receptor
Agonists
Antagonists
Unknown


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