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| Trade names | Neo-Cobefrine |
| Other names | Levonordefrin; α-Methylnorepinephrine; (–)-3,4-Dihydroxynorephedrine; 3,4,β-Trihydroxy-α-methylphenethylamine; 3,4,β-Trihydroxyamphetamine |
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| ECHA InfoCard | 100.113.606 |
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| Formula | C9H13NO3 |
| Molar mass | 183.207 g·mol−1 |
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Corbadrine, sold under the brand nameNeo-Cobefrine and also known aslevonordefrin andα-methylnorepinephrine, is acatecholaminesympathomimetic used as atopicalnasaldecongestant andvasoconstrictor indentistry in theUnited States.[1][2][3] It is usually used in a pre-mixed solution withlocal anesthetics, such asmepivacaine.[4]
The drug acts as anon-selectiveagonist of theα1-,α2-, andβ-adrenergic receptors.[5][6][7] It is said to have preferential activity at the α2-adrenergic receptor.[5][7]
Corbadrine is also ametabolite of theantihypertensive drugmethyldopa and plays a role in itspharmacology and effects.[8]
Corbadrine ismetabolized primarily bycatecholO-methyltransferase (COMT).[7]
Corbadrine, also known as 3,4,β-trihydroxy-α-methylphenethylamine or as 3,4,β-trihydroxyamphetamine, as well as α-methylnorepinephrine or (–)-3,4-dihydroxynorephedrine, is asubstituted phenethylamine andamphetaminederivative.[1][3]
Analogues of corbadrine includeα-methyldopamine,dioxifedrine (3,4-dihydroxyephedrine; α-methylepinephrine),dioxethedrin (3,4-dihydroxy-N-ethylnorephedrine; α-methyl-N-ethylnorepinephrine), andhydroxyamphetamine (4-hydroxyamphetamine; α-methyltyramine).
Corbadrine is thegeneric name of the drug and itsINNTooltip International Nonproprietary Name.[1][3][2] It is also known aslevonordefrin, which is itsUSANTooltip United States Adopted Name.[1][3][2] Synonyms of corbadrine includeα-methylnorepinephrine and(–)-3,4-dihydroxynorephedrine.[9] The drug has been sold under the brand nameNeo-Cobefrine.[3]
