Theleukemia inhibitory factor (LIF) is a polyfunctionalcytokine that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. LIF action appears to be mediated through a high-affinity receptor complex composed of a low-affinity LIF binding chain (LIF receptor) and a high-affinity converter subunit,glycoprotein 130 (IL6ST, gp130). Both LIFR and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems, including theciliary neurotrophic factor,growth hormone andprolactin.[5]
Leukemia inhibitory factor receptor has been shown tointeract with glycoprotein 130.[6][7]
LIFR has also been identified as a breast cancer metastasis suppressor that functions through theHippo-YAP pathway. LIFR is down regulated in a number ofbreast carcinomas and may serve a prognostic tool.
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Kojima K, Kanzaki H, Iwai M, Hatayama H, Fujimoto M, Narukawa S, Higuchi T, Kaneko Y, Mori T, Fujita J (July 1995). "Expression of leukaemia inhibitory factor (LIF) receptor in human placenta: a possible role for LIF in the growth and differentiation of trophoblasts".Human Reproduction.10 (7):1907–11.doi:10.1093/oxfordjournals.humrep.a136205.PMID8583009.
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