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Letosteine

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Chemical compound

Pharmaceutical compound

Letosteine
Clinical data

Trade names	Viscotiol
Other names	2-[2-(ethoxycarbonylmethylsulfanyl)ethyl]-1,3-thiazolidine-4-carboxylic acid
Routes of administration	Oral (gastroresistantcapsules)
ATC code	R05CB09 (WHO)
Identifiers
IUPAC name 2-[2-(2-ethoxy-2-oxoethyl)sulfanylethyl]-1,3-thiazolidine-4-carboxylic acid
CAS Number	53943-88-7^Y
PubChemCID	68707
DrugBank	DB08939^N
ChemSpider	61958^Y
UNII	6MVF9U95DW
KEGG	D07380^Y
ChEBI	CHEBI:88271^N
CompTox Dashboard(EPA)	DTXSID70866372
ECHA InfoCard	100.053.509
Chemical and physical data
Formula	C₁₀H₁₇NO₄S₂
Molar mass	279.37 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C(O)C1NC(SC1)CCSCC(=O)OCC
InChI InChI=1S/C10H17NO4S2/c1-2-15-9(12)6-16-4-3-8-11-7(5-17-8)10(13)14/h7-8,11H,2-6H2,1H3,(H,13,14)^Y Key:IKOCLISPVJZJEA-UHFFFAOYSA-N^Y
^NY (what is this?) (verify)

Letosteine is amucolytic^[1]patented (U.S. patent 6987120) by Piero del Soldato ofMilan, Italy.^[2] He filed his application in 2000.

^Zhou Y, Sun S, Liu H, Cui L, Chang X, Sun Z (November 2014). "Efficacy and safety of letosteine in the treatment of sputum thickening and expectoration difficulty in patients with respiratory diseases: a multicenter, randomized, double-masked, double dummy, positive drug parallel controlled trial".Die Pharmazie.69 (11):842–9.PMID 25985582.
^US 6987120, del Soldato P, "Pharmaceutical compounds", issued 17 January 2006, assigned to Nicox SA

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