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Lerdelimumab

From Wikipedia, the free encyclopedia
Monoclonal antibody
Pharmaceutical compound
Lerdelimumab
Monoclonal antibody
TypeWhole antibody
SourceHuman
TargetTGF beta 2
Clinical data
ATC code
  • none
Legal status
Legal status
  • Development discontinued
Identifiers
CAS Number
ChemSpider
  • none
UNII
 ☒NcheckY (what is this?)  (verify)

Lerdelimumab (CAT-152, intended trade nameTrabio) is ahumanmonoclonal antibody and animmunosuppressive drug targetingTGF beta 2.

It was being developed to reduce scarring afterglaucoma drainage surgery.[1] Development was stopped in late 2005 after unsuccessful trial results for that condition.[2]

References

[edit]
  1. ^"Lerdelimumab".Drugs in R&D.3 (2):106–8. 1 February 2002.doi:10.2165/00126839-200203020-00006.PMID 12001808.
  2. ^"CAT abandons Trabio after second clinical trial failure".The Pharma Letter. 28 March 2005.
Intracellular
(initiation)
Antimetabolites
Macrolides/
otherIL-2 inhibitors
IMiDs
JAK inhibitors
Intracellular
(reception)
IL-1 receptor antagonists
mTOR
Extracellular
Antibodies
Monoclonal
Serum target
(noncellular)
Cellular
target
Unsorted
Polyclonal
-cept (Fusion)
Unsorted
Immune system
Human
Mouse
Chimeric
Humanized
Chimeric + humanized
Interleukin
Human
Humanized
Veterinary
Inflammatorylesions
Mouse
Type I
ALK1 (ACVRL1)
ALK2 (ACVR1A)
ALK3 (BMPR1A)
ALK4 (ACVR1B)
ALK5 (TGFβR1)
ALK6 (BMPR1B)
ALK7 (ACVR1C)
Type II
TGFβR2
BMPR2
ACVR2A (ACVR2)
ACVR2B
AMHR2 (AMHR)
Type III
TGFβR3 (β-glycan)
Unsorted
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