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Leaky gut syndrome

From Wikipedia, the free encyclopedia
Hypothetical medical condition
This article is about a proposed medical condition in alternative medicine. For the phenomenon ("leaky gut") whereby the intestine wall exhibits excessive permeability, seeIntestinal permeability.
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Alternative medicine
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Leaky gut syndrome is a hypothetical and medically unrecognized condition[1][2] that is distinct from the scientific phenomenon ofincreased intestinal permeability commonly known as "leaky gut".[1][3] Claims for the existence of "leaky gut syndrome" as a distinct medical condition come mostly fromnutritionists and practitioners ofalternative medicine.[1][4][5] Proponents claim that a "leaky gut" causeschronic inflammation throughout the body that results in a wide range of conditions, includingmyalgic encephalomyelitis/chronic fatigue syndrome,rheumatoid arthritis,lupus,migraines,multiple sclerosis, andautism.[1][4] There is little evidence to support this hypothesis.[1][6]

Stephen Barrett has described "leaky gut syndrome" as afad diagnosis and says that its proponents use the alleged condition as an opportunity to sell a number of alternative-health remedies – including diets, herbal preparations, and dietary supplements.[5] Promoters ofpseudoscience have claimed that the passage of proteins through a "leaky" gut is the cause of autism.[7] Evidence for claims that a leaky gut causes autism is weak and conflicting.[8]

Advocates tout various treatments for "leaky gut syndrome", such asdietary supplements,probiotics, herbal remedies,gluten-free foods, and low-FODMAP, low-sugar, and/or antifungal diets, but there is little evidence that the treatments offered are of benefit.[1]None have been adequately tested to determine whether they are safe and effective for this purpose.[4] The UKNational Institute for Health and Care Excellence (NICE) does not recommend the use of any special diets to manage the main symptoms of autism or leaky gut syndrome.[1]

See also

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References

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  1. ^abcdefg"Leaky gut syndrome".NHS Choices. 26 February 2015. Archived fromthe original on 2018-02-11. Retrieved15 August 2016.
  2. ^"Debunking the Myth of 'Leaky Gut Syndrome'".Inside Tract (187). Canadian Society of Intestinal Research. 2013.
  3. ^Bischoff, Stephan C; Barbara, Giovanni; Buurman, Wim; Ockhuizen, Theo; Schulzke, Jörg-Dieter; Serino, Matteo; Tilg, Herbert; Watson, Alastair; Wells, Jerry M (2014)."Intestinal permeability – a new target for disease prevention and therapy".BMC Gastroenterology.14 (1): 189.doi:10.1186/s12876-014-0189-7.ISSN 1471-230X.PMC 4253991.PMID 25407511.
  4. ^abcOdenwald, Matthew A.; Turner, Jerrold R. (2013)."Intestinal Permeability Defects: Is It Time to Treat?".Clinical Gastroenterology and Hepatology.11 (9):1075–83.doi:10.1016/j.cgh.2013.07.001.PMC 3758766.PMID 23851019.
  5. ^abBarrett, Stephen (14 March 2009)."Be Wary of 'Fad' Diagnoses".Quackwatch. Retrieved24 October 2013.
  6. ^Quigley, Eamonn Martin (2016). "Leaky gut – concept or clinical entity?".Curr Opin Gastroenterol (Review).32 (2):74–79.doi:10.1097/MOG.0000000000000243.PMID 26760399.S2CID 40590775.
  7. ^Kalichman, Seth C. (2009).Denying AIDS: Conspiracy Theories, Pseudoscience, and Human Tragedy. Springer. p. 167.ISBN 9780387794761.
  8. ^Rao, Meenakshi; Gershon, Michael David (2016)."The bowel and beyond: the enteric nervous system in neurological disorders".Nat Rev Gastroenterol Hepatol (Review).13 (9):517–28.doi:10.1038/nrgastro.2016.107.PMC 5005185.PMID 27435372.
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