This gene encodes a member of thelatrophilin subfamily ofG protein-coupled receptors (GPCR). Latrophilins may function in bothcell adhesion andsignal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellularN-terminal cell adhesion subunit and a subunit with substantial similarity to thesecretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane.[6]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Hayflick JS (Jan 2001). "A family of heptahelical receptors with adhesion-like domains: a marriage between two super families".Journal of Receptor and Signal Transduction Research.20 (2–3):119–131.doi:10.3109/10799890009150640.PMID10994649.S2CID19919738.
Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB (July 2004). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors".Genomics.84 (1):23–33.doi:10.1016/j.ygeno.2003.12.004.PMID15203201.
