Lysyl oxidase homolog 3 is anenzyme that in humans is encoded by theLOXL3gene.[5][6]
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. TheN-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, andchemotaxis to each member of the family. Alternatively spliced transcript variants of this gene have been reported but their full-length nature has not been determined.[6]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Jourdan-Le Saux C, Tomsche A, Ujfalusi A, Jia L, Csiszar K (Jun 2001). "Central nervous system, uterus, heart, and leukocyte expression of the LOXL3 gene, encoding a novel lysyl oxidase-like protein".Genomics.74 (2):211–8.doi:10.1006/geno.2001.6545.PMID11386757.
^Alzahrani F, Al Hazzaa SA, Tayeb H, Alkuraya FS (2015). "LOXL3, encoding lysyl oxidase-like 3, is mutated in a family with autosomal recessive Stickler syndrome".Hum. Genet.134 (4):451–3.doi:10.1007/s00439-015-1531-z.PMID25663169.S2CID9869276.
Molnar J, Fong KS, He QP, et al. (2003). "Structural and functional diversity of lysyl oxidase and the LOX-like proteins".Biochim. Biophys. Acta.1647 (1–2):220–4.doi:10.1016/s1570-9639(03)00053-0.PMID12686136.
Akagawa H, Narita A, Yamada H, et al. (2007). "Systematic screening of lysyl oxidase-like (LOXL) family genes demonstrates that LOXL2 is a susceptibility gene to intracranial aneurysms".Hum. Genet.121 (3–4):377–87.doi:10.1007/s00439-007-0333-3.PMID17287949.S2CID25771968.
Huang Y, Dai J, Tang R, et al. (2001). "Cloning and characterization of a human lysyl oxidase-like 3 gene (hLOXL3)".Matrix Biol.20 (2):153–7.doi:10.1016/S0945-053X(01)00124-X.PMID11334717.
