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LILRA3

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

LILRA3

Available structures

PDB

Human UniProt search:PDBe RCSB

List of PDB id codes
3Q2C

Identifiers

Aliases

LILRA3, CD85E, HM31, HM43, ILT-6, ILT6, LIR-4, LIR4, leukocyte immunoglobulin like receptor A3

External IDs

OMIM:604818;GeneCards:LILRA3;OMA:LILRA3 - orthologs

RNA expression pattern

Bgee

Human

Mouse (ortholog)

n/a

BioGPS


More reference expression data

Gene ontology
Molecular function	antigen binding signaling receptor activity
Cellular component	extracellular region plasma membrane specific granule membrane tertiary granule membrane ficolin-1-rich granule membrane
Biological process	defense response adaptive immune response signal transduction immune system process neutrophil degranulation
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


11026


n/a

Ensembl


n/a


n/a

UniProt


Q8N6C8


n/a

RefSeq (mRNA)


NM_001172654 NM_006865


n/a

RefSeq (protein)


NP_001166125 NP_006856


n/a

Location (UCSC)

n/a

PubMed search

^[1]

n/a

Wikidata

View/Edit Human

Leukocyte immunoglobulin-like receptor subfamily A member 3 (LILR-A3) also known asCD85 antigen-like family member E (CD85e),immunoglobulin-like transcript 6 (ILT-6), andleukocyte immunoglobulin-like receptor 4 (LIR-4) is aprotein that in humans is encoded by theLILRA3gene located within theleukocyte receptor complex on chromosome 19q13.4. Unlike many of its family, LILRA3 lacks a transmembrane domain. The function of LILRA3 is currently unknown; however, it is highly homologous to other LILR genes,^[2] and can bindhuman leukocyte antigen (HLA) class I. Therefore, if secreted, the LILRA3 might impair interactions of membrane-bound LILRs (such asLILRB1, an inhibitory receptor expressed on effector and memoryCD8 T cells) with their HLA ligands, thus modulating immune reactions and influencing susceptibility to disease.^[3]^[4]^[5]

Like the closely relatedLILRA1, LILRA3 binds to both normal and 'unfolded' free heavy chains of HLA class I, with a preference for free heavy chains of HLA-C alleles^[6]

References

[edit]

^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Torkar M, Haude A, Milne S, Beck S, Trowsdale J, Wilson MJ (December 2000). "Arrangement of the ILT gene cluster: a common null allele of the ILT6 gene results from a 6.7-kbp deletion".European Journal of Immunology.30 (12):3655–62.doi:10.1002/1521-4141(200012)30:12<3655::aid-immu3655>3.0.co;2-y.PMID 11169408.S2CID 38450831.
^Arm JP, Nwankwo C, Austen KF (September 1997)."Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor".Journal of Immunology.159 (5):2342–9.doi:10.4049/jimmunol.159.5.2342.PMID 9278324.S2CID 45021877.
^Borges L, Hsu ML, Fanger N, Kubin M, Cosman D (December 1997)."A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules".Journal of Immunology.159 (11):5192–6.doi:10.4049/jimmunol.159.11.5192.PMID 9548455.S2CID 36907307.
^"Entrez Gene: LILRA3 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3".
^Jones DC, Kosmoliaptsis V, Apps R, Lapaque N, Smith I, Kono A, Chang C, Boyle LH, Taylor CJ, Trowsdale J, Allen RL (March 2011)."HLA class I allelic sequence and conformation regulate leukocyte Ig-like receptor binding".Journal of Immunology.186 (5):2990–7.doi:10.4049/jimmunol.1003078.PMID 21270408.

External links

[edit]

LILRA3+protein,+human at the U.S. National Library of MedicineMedical Subject Headings (MeSH)
Overview of all the structural information available in thePDB forUniProt:Q8N6C8 (Leukocyte immunoglobulin-like receptor subfamily A member 3) at thePDBe-KB.

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

v t e Proteins:clusters of differentiation (see alsolist of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 -CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 -CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350