Ligatin, otherwise known aseIF2D, is aprotein that in humans is encoded by theLGTNgene.[5][6] This protein is not a component of the heterotrimericeIF2 complex, but instead functions in different pathways ofeukaryotic translation.
This gene encodes a protein receptor that localizes phosphoglycoproteins withinendosomes and at the cell periphery. This trafficking receptor for phosphoglycoproteins may play a role inneuroplasticity by modulating cell-cell interactions, intracellular adhesion, and protein binding at membrane surfaces. Inhippocampal neurons, long-lasting down-regulation of ligation mRNA levels occurs via post-transcriptional RNA processing followingglutamate receptor activation. This protein contains singlePUA andSUI1 domains and these domains may function in RNA binding and translation initiation, respectively.[6]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Jakoi ER, Brown AL, Ho YS, Snyderman R (June 1989). "Molecular cloning of the cDNA for ligatin".Journal of Cell Science. 93 ( Pt 2) (2):227–32.doi:10.1242/jcs.93.2.227.PMID2482295.
Gaston SM, Marchase RB, Jakoi ER (1982). "Brain ligatin: a membrane lectin that binds acetylcholinesterase".Journal of Cellular Biochemistry.18 (4):447–59.doi:10.1002/jcb.1982.240180406.PMID7085778.S2CID22975039.
Marchase RB, Koro LA, Kelly CM, McClay DR (1982). "A possible role for ligatin and the phosphoglycoproteins it binds in calcium-dependent retinal cell adhesion".Journal of Cellular Biochemistry.18 (4):461–8.doi:10.1002/jcb.1982.240180407.PMID7085779.S2CID44992995.
Jakoi ER, Kempe K, Gaston SM (1982). "Ligatin binds phosphohexose residues on acidic hydrolases".Journal of Supramolecular Structure and Cellular Biochemistry.16 (2):139–53.doi:10.1002/jsscb.1981.380160205.PMID7299841.
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".Gene.138 (1–2):171–4.doi:10.1016/0378-1119(94)90802-8.PMID8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".Gene.200 (1–2):149–56.doi:10.1016/S0378-1119(97)00411-3.PMID9373149.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007)."Large-scale mapping of human protein-protein interactions by mass spectrometry".Molecular Systems Biology.3 (1): 89.doi:10.1038/msb4100134.PMC1847948.PMID17353931.
