LEFTY1
Identifiers
Aliases	LEFTY1, LEFTB, LEFTYB, left-right determination factor 1
External IDs	OMIM:603037;MGI:107405;HomoloGene:49231;GeneCards:LEFTY1;OMA:LEFTY1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q42.12 Start 225,886,282bp[1] End 225,911,382bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H4 Start 180,762,587bp[2] End 180,765,965bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon body of pancreas rectum testicle gonad endometrium appendix epithelium of colon monocyte cerebellar hemisphere Top expressed in neural plate lateral plate mesoderm primitive endoderm Region I of hippocampus proper endothelial cell of lymphatic vessel lip ankle joint embryo islet of Langerhans skin of external ear More reference expression data BioGPS n/a
Gene ontology Molecular function transforming growth factor beta receptor binding cytokine activity growth factor activity Cellular component extracellular region extracellular space Biological process regulation of apoptotic process multicellular organism development positive regulation of pathway-restricted SMAD protein phosphorylation heart morphogenesis determination of left/right symmetry negative regulation of transcription by RNA polymerase II transforming growth factor beta receptor signaling pathway regulation of MAPK cascade SMAD protein signal transduction cell development BMP signaling pathway regulation of signaling receptor activity Sources:Amigo /QuickGO
Orthologs Species Human Mouse Entrez 10637 13590 Ensembl ENSG00000243709 ENSMUSG00000038793 UniProt O75610 Q64280 RefSeq (mRNA) NM_020997 NM_010094 RefSeq (protein) NP_066277 NP_034224 Location (UCSC) Chr 1: 225.89 – 225.91 Mb Chr 1: 180.76 – 180.77 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Left-right determination factor 1 is aprotein that in humans is encoded by the LEFTY1gene.^[5]

This gene encodes a member of theTGF-beta family of proteins. A similar secreted protein in mouse plays a role in left-right asymmetry determination of organ systems during development. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a relatedpseudogene.

• Lefty
  • Lefty-1

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

This article on agene on humanchromosome 1 is astub. You can help Wikipedia byexpanding it.

• v
• t
• e

• Genes on human chromosome 1
• Human chromosome 1 gene stubs

• Articles with short description
• Short description matches Wikidata
• Wikipedia articles incorporating text from the United States National Library of Medicine
• All stub articles