Movatterモバイル変換

L-745,870

From Wikipedia, the free encyclopedia

Chemical compound

Pharmaceutical compound

L-745,870
Identifiers

IUPAC name 3-([4-(4-chlorophenyl)piperazin-1-yl]methyl)-1H-pyrrolo[2,3-b]pyridine
CAS Number	158985-00-3^Y
PubChemCID	5311200
IUPHAR/BPS	3303
ChemSpider	4470720^N
UNII	J3OLN3XSX7
ChEMBL	ChEMBL267014^N
CompTox Dashboard(EPA)	DTXSID40415513
Chemical and physical data
Formula	C₁₈H₁₉ClN₄
Molar mass	326.83 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES c1cc2c(c[nH]c2nc1)CN3CCN(CC3)c4ccc(cc4)Cl
InChI InChI=1S/C18H19ClN4/c19-15-3-5-16(6-4-15)23-10-8-22(9-11-23)13-14-12-21-18-17(14)2-1-7-20-18/h1-7,12H,8-11,13H2,(H,20,21)^N Key:OGJGQVFWEPNYSB-UHFFFAOYSA-N^N
^NY (what is this?) (verify)

L-745,870 is a drug which acts as adopamine receptor antagonist selective for theD₄ subtype, and hasantipsychotic effects in animal models, though it was not effective in human trials.^[1]^[2]^[3]

^Bristow LJ, Kramer MS, Kulagowski J, Patel S, Ragan CI, Seabrook GR (June 1997). "Schizophrenia and L-745,870, a novel dopamine D4 receptor antagonist".Trends in Pharmacological Sciences.18 (6):186–8.doi:10.1016/s0165-6147(97)01066-3.PMID 9226994.
^Zhang K, Grady CJ, Tsapakis EM, Andersen SL, Tarazi FI, Baldessarini RJ (September 2004)."Regulation of working memory by dopamine D4 receptor in rats".Neuropsychopharmacology.29 (9):1648–55.doi:10.1038/sj.npp.1300491.PMID 15138447.
^Moustgaard A, Hau J, Lind NM (2008)."Effects of dopamine D4 receptor antagonist on spontaneous alternation in rats".Behavioral and Brain Functions.4: 49.doi:10.1186/1744-9081-4-49.PMC 2577092.PMID 18945334.

Agonists	Benzazepines:6-Br-APB Fenoldopam SKF-38,393 SKF-77,434 SKF-81,297 SKF-82,958 SKF-83,959 Trepipam Zelandopam Ergolines:Cabergoline CY-208,243 Dihydroergocryptine LEK-8829 Lisuride Pergolide Terguride Dihydrexidine derivatives:A-77636 A-86929 Adrogolide (ABT-431, DAS-431) Dihydrexidine Dinapsoline Dinoxyline Doxanthrine Phenethylamines:BCO-001 Deoxyepinephrine (N-methyldopamine, epinine) Dopexamine Etilevodopa Ibopamine L-DOPA (levodopa) Melevodopa L-Phenylalanine L-Tyrosine XP21279 Others:A-68930 Apomorphine Isocorypalmine Nuciferine PF-6649751 PF 6669571 Propylnorapomorphine Rotigotine SKF-89,145 SKF-89,626 Stepholidine Tavapadon Tetrahydropalmatine
PAMs	Tetrahydroisoquinolines:DETQ DPTQ Mevidalen
Antagonists	Typical antipsychotics:Butaclamol Chlorpromazine Chlorprothixene Flupentixol (flupenthixol) (+melitracen) Fluphenazine Loxapine Perphenazine (+amitriptyline) Pifluthixol Thioridazine Thiothixene Trifluoperazine (+tranylcypromine) Zuclopenthixol Atypical antipsychotics:Asenapine Clorotepine Clotiapine Clozapine DHA-clozapine Fluperlapine Iloperidone Norclozapine Norquetiapine Olanzapine (+fluoxetine) Paliperidone Quetiapine Risperidone Tefludazine Zicronapine Ziprasidone Zotepine Others:Berupipam Ecopipam EEDQ Metitepine (methiothepin) Odapipam Perlapine SCH-23390

Agonists

Antagonists

Thisdrug article relating to thenervous system is astub. You can help Wikipedia byexpanding it.

Hidden categories: