 | |
| Names | |
|---|---|
| IUPAC name 7-Chloro-4-hydroxy-3-(3-phenoxyphenyl)-1H-quinolin-2-one | |
| Identifiers | |
3D model (JSmol) | |
| ChEBI | |
| ChEMBL | |
| ChemSpider | |
| ECHA InfoCard | 100.162.301 |
| EC Number |
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| UNII | |
| |
| |
| Properties | |
| C21H14ClNO3 | |
| Molar mass | 363.80 g·mol−1 |
| Hazards | |
| GHS labelling:[1] | |
 | |
| Warning | |
| H315,H319,H335 | |
| P261,P264,P264+P265,P271,P280,P302+P352,P304+P340,P305+P351+P338,P319,P321,P332+P317,P337+P317,P362+P364,P403+P233,P405,P501 | |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
L-701324 is anantagonist of theNMDA receptor. It appears to have activity inanimal models of depression.
L-701324 appears to be an antagonist of the NMDA receptor and acts at theglycine binding site.[2] This means that it prevents the receptor from activating by blocking the binding of glycine, a required co-agonist in addition toglutamate.
L-701324 exhibited antidepressant behavior in mice by reducing depression-like behavior caused by theforced swimming test, thetail suspension test, and the chronic unpredictable mild stress model.[3]
In another animal study, a combination of anadenosine receptor antagonist, such ascaffeine, with an NMDA receptor antagonist, such as L-701324, showed a synergistic effect that might have use as an antidepressant.[4]