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L-687,384

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Chemical compound
Pharmaceutical compound
L-687,384
Clinical data
ATC code
  • none
Identifiers
  • 1'-benzylspiro[2,3-dihydro-1H-naphthalene-4,4'-piperidine]
CAS Number
PubChemCID
ChemSpider
UNII
ChEMBL
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC21H25N
Molar mass291.438 g·mol−1
3D model (JSmol)
  • c3ccccc3CN2CCC1(CC2)CCCc4c1cccc4
  • InChI=1S/C21H25N/c1-2-7-18(8-3-1)17-22-15-13-21(14-16-22)12-6-10-19-9-4-5-11-20(19)21/h1-5,7-9,11H,6,10,12-17H2 ☒N
  • Key:MLDCBJPLHBPJET-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

L-687,384 is asigma receptoragonist, selective for theσ1 subtype,[1] as well as anNMDA antagonist.[2]

See also

[edit]
Spipethiane[3]

References

[edit]
  1. ^Bergeron R, Debonnel G (February 1997). "Effects of low and high doses of selective sigma ligands: further evidence suggesting the existence of different subtypes of sigma receptors".Psychopharmacology.129 (3):215–24.doi:10.1007/s002130050183.PMID 9084059.S2CID 24537111.
  2. ^McLarnon J, Sawyer D, Church J (June 1994). "The actions of L-687,384, a sigma receptor ligand, on NMDA-induced currents in cultured rat hippocampal pyramidal neurons".Neuroscience Letters.174 (2):181–4.doi:10.1016/0304-3940(94)90016-7.PMID 7526288.S2CID 10876486.
  3. ^Quaglia W, Giannella M, Piergentili A, Pigini M, Brasili L, Di Toro R, Rossetti L, Spampinato S, Melchiorre C. 1'-Benzyl-3,4-dihydrospiro[2H-1- benzothiopyran-2,4'-piperidine] (spipethiane), a potent and highly selective sigma1 ligand. J Med Chem. 1998 May 7;41(10):1557-60. doi: 10.1021/jm970740r. PMID 9572880.
AMPARTooltip α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor
KARTooltip Kainate receptor
NMDARTooltip N-Methyl-D-aspartate receptor
Group I
mGluR1Tooltip Metabotropic glutamate receptor 1
mGluR5Tooltip Metabotropic glutamate receptor 5
Group II
mGluR2Tooltip Metabotropic glutamate receptor 2
mGluR3Tooltip Metabotropic glutamate receptor 3
Group III
mGluR4Tooltip Metabotropic glutamate receptor 4
mGluR6Tooltip Metabotropic glutamate receptor 6
mGluR7Tooltip Metabotropic glutamate receptor 7
mGluR8Tooltip Metabotropic glutamate receptor 8
σ1
σ2
Unsorted


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