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Kyle Biggar

From Wikipedia, the free encyclopedia
Canadian biochemist and molecular biologist
This articleis anorphan, as no other articleslink to it. Pleaseintroduce links to this page fromrelated articles.(November 2018)
Kyle Biggar
Born1986 (age 38–39)
AwardsJohn Charles Polanyi Prize (2016)

Kyle K. Biggar (born 1986) is a Canadianbiochemist andmolecular biologist. He has been a professor ofbiochemistry,chemistry, andbiology atCarleton University inOttawa, Canada since 2017. Biggar was the 2016 recipient of the John Charles Polanyi Prize for his outstanding work in early career research.[1]

Biography

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Kyle Kevin Biggar was born in 1986 inSummerside, Prince Edward Island. Biggar studiedBiology andChemistry atSt. Francis Xavier University (B.Sc) in Antigonish, Nova-Scotia, Canada, and Biology and Biochemistry atCarleton University (Ph.D 2013).[1][2] His doctoral research focused on the biochemistry of physiological stress response. The well-known Canadian biochemistKenneth B. Storey was his thesis advisor during his graduate studies at Carleton University. After completing a post-doctoral fellowship at theUniversity of Western Ontario Schulich School of Medicine and Dentistry, Biggar came back to his alma mater to become an assistant professor of Biochemistry as of 2016.[3]

Research

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Biggar's research includes many different areas from different fields within molecular biology, biochemistry, and physical biochemistry. His main areas of research interest areOxidative Cell Stress,[4]Functional Proteomics,[5]Bioinformatics,[6] andMolecular Pharmacology.[7] He is particularly known for his research in the new field of Non-histone Lysine Methylation and its relation to both functional proteomics and cell stress.

Professional honours

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Biggar was the 2016 recipient of the John Charles Polanyi Prize for outstanding work in early career research in peptide therapeutics.[8]

Selected recent publications

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  • Biggar, K.K., and Storey, K.B. Functional impact of non-coding RNA regulation in extreme stress adaptation. J. Mol. Cell. Biol. In Press. doi.org/10.1093/jmcb/mjx053[9]
  • Biggar, K.K., Wang Z. and Li, S. SnapShot: Lysine methylation beyond histones. Mol. Cell 68(5):1016–1016.e1. Invited submission
  • Singal, S.S., Nygard, K.*, Biggar, K.K.*, Shehab, M.A., S.S.C. Li, Jansson, T. and Gupta, M.B. Interaction between IGFBP-1, protein kinase CSNK-2 and mTOR in HepG2 cells as demonstrated by dual immunofluorescence andin situ PLA. Am. J. Pathol.In press,doi.org/10.1016/j.ajpath.2017.09.009
  • Biggar, K.K., Dawson, N.J. and Storey, K.B. Native protein denaturation using urea. Biotechniques 62(1): xiii (epub)
  • Shehab, M.A., Biggar, K.K., Singal, S.S., Nygard, K., Li, S.S.C., Jansson, T. and Gupta, M.B. Exposure of decidualized HESC to low oxygen tension and leucine deprivation results in increased IGFBP-1 phosphorylation and reduced IGF-I bioactivity. Mol. Cell. Endo. 452:1-14
  • Wu, Z., Connolly, J. and Biggar, K.K. Beyond histones: The expanding roles of lysine methylation. FEBS J. 284(17): 2732-2744
  • Biggar, K.K. and Storey, K.B. Exploration of low temperature microRNA function in an anoxia tolerant vertebrate ectotherm, the red eared slider turtle (Trachemys scripta elegans). J. Thermal Biol. In Press
  • Wu, C.W., Biggar, K.K., Luu, B.E., Szereszewski, K.E. and Storey, K.B. Analysis of microRNA expression during the torpor-arousal cycle of a mammalian hibernator, the 13-lined ground squirrel. Physiol. Genomics DOI: 10.1152/physiolgenomics.00005.2016

References

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  1. ^ab"Kyle Biggar Wins Polanyi Research Prize for Fighting Cancer".Carleton University. Retrieved15 March 2018.
  2. ^"Kyle Biggar - Department of Biology".carleton.ca. Retrieved2018-03-19.
  3. ^"Kyle K Biggar | Ph.D | Carleton University, Ottawa | Institute of Biochemistry | ResearchGate".ResearchGate. Retrieved2018-03-19.
  4. ^"Environmental stress".biggarlab.dudaone.com. Retrieved2018-03-19.
  5. ^"Functional proteomics".biggarlab.dudaone.com. Retrieved2018-03-19.
  6. ^"Bioinformatics".biggarlab.dudaone.com. Retrieved2018-03-19.
  7. ^"Molecular Pharmacology".biggarlab.dudaone.com. Retrieved2018-03-19.
  8. ^"2016 John Charles Polanyi Prize Winners | Council of Ontario Universities".Council of Ontario Universities. Retrieved2018-03-20.
  9. ^"Publications".biggarlab.dudaone.com. Retrieved2018-03-19.
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