It is used for the treatment of anxiety and has similar effectiveness compared to diazepam. Ketazolam also appears to produce reduced levels of side effects such as sedation compared withdiazepam and the side effects when they occur tend to be milder.[3][4][5][6] Ketazolam is also an effective antispasmodic drug and is used for the treatment of spasticity.[7][8][9]
Benzodiazepines require special precaution if used in the elderly, during pregnancy, in children, alcohol or drug-dependent individuals and individuals withcomorbidpsychiatric disorders.[14]
Ketazolam is a List 3 drug under theBetäubungsmittelgesetz, like almost all benzodiazepines in Germany. Ketazolam is a List II drugs of theOpium Law in theNetherlands. Ketazolam is aSchedule IV drug under the Controlled Substances Act in the US.[17]
^Anhalt HS, Young R, Roginsky M (November 1980). "Double-blind comparison of ketazolam, diazepam and placebo in once-a-day vs t.i.d. dosing".The Journal of Clinical Psychiatry.41 (11):386–392.PMID6108319.
^Kim KK, Sirman A, Trainor FS, Lee BY (1980). "Anxiolytic efficacy and safety of ketazolam compared with diazepam and placebo".Clinical Therapeutics.3 (1):9–14.PMID6105920.
^Fabre LF, Harris RT (1976). "Double-blind placebo-controlled efficacy study of ketazolam (U-28,774)".The Journal of International Medical Research.4 (1):50–54.doi:10.1177/030006057600400107.PMID16791.S2CID26311555.
^Rickels K, Csanalosi I, Greisman P, Mirman MJ, Morris RJ, Weise CC, Weiss G (October 1980). "Ketazolam and diazepam in anxiety: a controlled study".Journal of Clinical Pharmacology.20 (10):581–589.doi:10.1002/j.1552-4604.1980.tb01673.x.PMID6108335.S2CID6597368.
^Basmajian JV, Shankardass K, Russell D (August 1986). "Ketazolam once daily for spasticity: double-blind cross-over study".Archives of Physical Medicine and Rehabilitation.67 (8):556–557.PMID2874780.
^Basmajian JV, Shankardass K, Russell D, Yucel V (November 1984). "Ketazolam treatment for spasticity: double-blind study of a new drug".Archives of Physical Medicine and Rehabilitation.65 (11):698–701.PMID6149738.
^"Benzodiazepine Names". The Tranquilliser Recovery and Awareness Place. Archived fromthe original on 8 December 2008. Retrieved26 August 2008.
^Authier N, Balayssac D, Sautereau M, Zangarelli A, Courty P, Somogyi AA, et al. (November 2009). "Benzodiazepine dependence: focus on withdrawal syndrome".Annales Pharmaceutiques Françaises.67 (6):408–413.doi:10.1016/j.pharma.2009.07.001.PMID19900604.
^Joyce JR, Bal TS, Ardrey RE, Stevens HM, Moffat AC (June 1984). "The decomposition of benzodiazepines during analysis by capillary gas chromatography/mass spectrometry".Biomedical Mass Spectrometry.11 (6):284–289.doi:10.1002/bms.1200110607.PMID6743768.
