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Keratin 13

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

KRT13

Identifiers

Aliases

KRT13, CK13, K13, WSN2, keratin 13

External IDs

OMIM:148065;MGI:101925;HomoloGene:40740;GeneCards:KRT13;OMA:KRT13 - orthologs

Gene location (Human)

Chr.	Chromosome 17 (human)^[1]

Band	17q21.2	Start	41,500,981bp^[1]
Band	17q21.2	End	41,505,705bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	11 D\|11 63.41 cM	Start	100,008,153bp^[2]
Band	11 D\|11 63.41 cM	End	100,012,392bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

mucosa of pharynx

oral cavity

gums

gingival epithelium

body of tongue

buccal mucosa cell

palpebral conjunctiva

vulva

superior surface of tongue

cervix epithelium

Top expressed in

superior surface of tongue

esophagus

corneal stroma

molar

conjunctival fornix

umbilical cord

cervix

oral mucosa

middle ear

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	structural molecule activity protein binding
Cellular component	intermediate filament cytoskeleton keratin filament extracellular exosome intermediate filament nucleus cytosol
Biological process	cellular response to retinoic acid response to radiation cytoskeleton organization tongue morphogenesis keratinization cornification
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


3860


16663

Ensembl


ENSG00000171401


ENSMUSG00000044041

UniProt


P13646


P08730

RefSeq (mRNA)


NM_153490 NM_002274


NM_010662 NM_001313949

RefSeq (protein)


NP_002265 NP_705694


NP_001300878 NP_034792

Location (UCSC)

Chr 17: 41.5 – 41.51 Mb

Chr 11: 100.01 – 100.01 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Keratin 13 (orcytokeratin 13) is aprotein that in humans is encoded by theKRT13gene.^[5]^[6]

Keratin 13 is atype I cytokeratin, it is paired withkeratin 4 and found in the suprabasal layers of non-cornified stratified epithelia. Mutations in the gene encoding this protein and keratin 4 have been associated with the autosomal dominant disorderWhite Sponge Nevus.^[7]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000171401 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000044041 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Romano V, Raimondi E, Bosco P, Feo S, Di Pietro C, Leube RE, Troyanovsky SM, Ceratto N (October 1992). "Chromosomal mapping of human cytokeratin 13 gene (KRT13)".Genomics.14 (2):495–7.doi:10.1016/S0888-7543(05)80250-2.PMID 1385306.
^Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (July 2006)."New consensus nomenclature for mammalian keratins".J. Cell Biol.174 (2):169–74.doi:10.1083/jcb.200603161.PMC 2064177.PMID 16831889.
^Richard G, De Laurenzi V, Didona B, Bale SJ, Compton JG (December 1995)."Keratin 13 point mutation underlies the hereditary mucosal epithelial disorder white sponge nevus".Nat. Genet.11 (4):453–5.doi:10.1038/ng1295-453.PMID 7493031.S2CID 22769768.

Jacques CM, Pereira AL, Maia V, et al. (2009)."Expression of cytokeratins 10, 13, 14 and 19 in oral lichen planus"(PDF).J Oral Sci.51 (3):355–65.doi:10.2334/josnusd.51.355.PMID 19776502.
Sheng S, Barnett DH, Katzenellenbogen BS (2008)."Differential Estradiol and Selective Estrogen Receptor Modulator (SERM) Regulation of Keratin 13 Gene Expression and its Underlying Mechanism in Breast Cancer Cells".Mol. Cell. Endocrinol.296 (1–2):1–9.doi:10.1016/j.mce.2008.09.022.PMC 2654210.PMID 18951949.
Lu DP, Xing RD, Tatemoto Y, Osaki T (2006). "[Cytokeratin18, 13 and their gene expression in post-operative maxillary cyst linings with metaplastic epithelium]".Zhonghua Kou Qiang Yi Xue Za Zhi.41 (6):376–9.PMID 16836912.
Ceratto N, Dobkin C, Carter M, et al. (1997). "Human type I cytokeratin genes are a compact cluster".Cytogenet. Cell Genet.77 (3–4):169–74.doi:10.1159/000134566.PMID 9284906.
Olson GE, Winfrey VP, Blaeuer GL, et al. (2002)."Stage-specific expression of the intermediate filament protein cytokeratin 13 in luminal epithelial cells of secretory phase human endometrium and peri-implantation stage rabbit endometrium".Biol. Reprod.66 (4):1006–15.doi:10.1095/biolreprod66.4.1006.PMID 11906920.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".Gene.200 (1–2):149–56.doi:10.1016/S0378-1119(97)00411-3.PMID 9373149.
Suzuki H, Fukunishi Y, Kagawa I, et al. (2001)."Protein–Protein Interaction Panel Using Mouse Full-Length cDNAs".Genome Res.11 (10):1758–65.doi:10.1101/gr.180101.PMC 311163.PMID 11591653.
Rugg E, Magee G, Wilson N, et al. (1999). "Identification of two novel mutations in keratin 13 as the cause of white sponge naevus".Oral Dis.5 (4):321–4.doi:10.1111/j.1601-0825.1999.tb00097.x.PMID 10561721.
Olsen JV, Blagoev B, Gnad F, et al. (2006)."Global, in vivo, and site-specific phosphorylation dynamics in signaling networks".Cell.127 (3):635–48.doi:10.1016/j.cell.2006.09.026.PMID 17081983.S2CID 7827573.
Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)".Genome Res.14 (10B):2121–7.doi:10.1101/gr.2596504.PMC 528928.PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs".Nat. Genet.36 (1):40–5.doi:10.1038/ng1285.PMID 14702039.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".Gene.138 (1–2):171–4.doi:10.1016/0378-1119(94)90802-8.PMID 8125298.
Shibuya Y, Zhang J, Yokoo S, et al. (2003). "Constitutional mutation of keratin 13 gene in familial white sponge nevus".Oral Surg Oral Med Oral Pathol Oral Radiol Endod.96 (5):561–5.doi:10.1016/s1079-2104(03)00372-x.PMID 14600690.
Terrinoni A, Rugg EL, Lane EB, et al. (2001). "A novel mutation in the keratin 13 gene causing oral white sponge nevus".J. Dent. Res.80 (3):919–23.doi:10.1177/00220345010800031401.PMID 11379896.S2CID 12340591.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26):16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.
Waseem A, Alam Y, Dogan B, et al. (1998). "Isolation, sequence and expression of the gene encoding human keratin 13".Gene.215 (2):269–79.doi:10.1016/S0378-1119(98)00297-2.PMID 9714826.
Raspollini MR, Fambrini M, Marchionni M, et al. (2007). "In situ adenocarcinoma and squamous carcinoma of uterine cervix. Pathological and immunohistochemical analysis with cytokeratin 13".Eur. J. Obstet. Gynecol. Reprod. Biol.134 (2):249–53.doi:10.1016/j.ejogrb.2006.07.047.PMID 16949723.
Sajjan US, Sylvester FA, Forstner JF (2000)."Cable-Piliated Burkholderia cepacia Binds to Cytokeratin 13 of Epithelial Cells".Infect. Immun.68 (4):1787–95.doi:10.1128/IAI.68.4.1787-1795.2000.PMC 97349.PMID 10722565.

Proteins of thecytoskeleton

Human

Microfilaments
andABPs

Myofilament

Actins	A1 A2 B C1 G1 G2
Myosins	I MYO1A MYO1B MYO1C MYO1D MYO1E MYO1F MYO1G MYO1H) II MYH1 MYH2 MYH3 MYH4 MYH6 MYH7 MYH7B MYH8 MYH9 MYH10 MYH11 MYH13 MYH14 MYH15 MYH16 III MYO3A MYO3B V MYO5A MYO5B MYO5C VI MYO6 VII MYO7A MYO7B IX MYO9A MYO9B X MYO10 XV MYO15A XVIII MYO18A MYO18B LC MYL1 MYL2 MYL3 MYL4 MYL5 MYL6 MYL6B MYL7 MYL9 MYLIP MYLK MYLK2 MYLL1
Other	Tropomodulin 1 2 3 4 Troponin T 1 2 3 C 1 2 I 1 2 3 Tropomyosin 1 2 3 4 Actinin 1 2 3 4 Arp2/3 complex actin depolymerizing factors Cofilin 1 2 Destrin Gelsolin Profilin 1 2 Titin

Other

Intermediate
filaments

Type 1/2
(Keratin,
Cytokeratin)

Epithelial keratins (soft alpha-keratins)	type I/chromosome 17 9 10 12 13 14 15 16 17 19 20 chromosome 12 18 none 21 type II/chromosome 12 1 2A 3 4 5 6A 6B 6C 7 8
Hair keratins (hard alpha-keratins)	type I/chromosome 17 31 32 33A 33B 34 35 36 37 38 type II/chromosome 12 81 82 83 84 85 86
Ungrouped alpha	chromosome 17 23 24 25 26 27 28 39 40 chromosome 12 71 72 73 74 75 76 77 78 79 80
Not alpha	Beta-keratin

Type 3

Type 4

Type 5

Microtubules
andMAPs

Tubulins	TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA8 TUBB TUBB1 TUBB2A TUBB2B TUBB2C TUBB3 TUBB4 TUBB4Q TUBB6 TUBB8 TUBG1 TUBG2 TUBGCP2 TUBGCP3 TUBGCP4 TUBGCP5 TUBGCP6 TUBD1 TUBE1
MAPs	EB1 EB2 EB3 MAP1A MAP1B MAP2 MAP4
Kinesins	KIF1A KIF1B KIF2A KIF2C KIF3B KIF3C KIF4A KIF4B KIF5A KIF5B KIF5C KIF6 KIF7 KIF9 KIF11 KIF12 KIF13A KIF13B KIF14 KIF15 KIF16B KIF17 KIF18A KIF18B KIF19 KIF20A KIF20B KIF21A KIF21B KIF22 KIF23 KIF24 KIF25 KIF26A KIF26B KIF27 KIFC1 KIFC2 KIFC3
Dyneins	axonemal:DNAH1 DNAH2 DNAH3 DNAH5 DNAH6 DNAH7 DNAH8 DNAH9 DNAH10 DNAH11 DNAH12 DNAH13 DNAH14 DNAH17 DNAI1 DNAI2 DNALI1 DNAL1 DNAL4 cytoplasmic:DYNC1H1 DYNC2H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC2LI1 DYNLL1 DYNLL2 DYNLRB1 DYNLRB2 DYNLT1 DYNLT3
Microtubule organising proteins	CAMSAP1 CAMSAP2 CAMSAP3 Centrin 1 Centrin 2 Centrin 3 PCM1
Microtubule severing proteins	Katanin Spastin
Other	Tau protein Dynactin DCTN1 Stathmin Tektin TEKT1 TEKT2 TEKT3 TEKT4 TEKT5 Dynamin DNM1 DNM2 DNM3