Keratin 1 is a Type IIintermediate filament (IFs) of the intracytoplasmatic cytoskeleton. Is co-expressed with and binds toKeratin 10, a Type I keratin, to form a coiled coil heterotypic keratin chain. Keratin 1 and Keratin 10 are specifically expressed in the spinous and granular layers of theepidermis.[5] In contrast, basal layer keratinocytes express little to no Keratin 1. Mutations inKRT1, the gene encoding Keratin 1, have been associated with variants of the diseasebullous congenital ichthyosiform erythroderma in which the palms and soles of the feet are affected. Mutations inKRT10 have also been associated with bullous congenital ichthyosiform erythroderma; however, in patients with KRT10 mutations the palms and soles are spared. This difference is likely due toKeratin 9, rather than Keratin 10, being the major binding partner of Keratin 1 in acral (palm and sole) keratinocytes.[6]
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