Kallikrein-5, formerly known as stratum corneum tryptic enzyme (SCTE), is aserine protease expressed in theepidermis. In humans it is encoded by theKLK5gene.[5][6][7][8][9][10] This gene is one of the fifteenkallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated byestrogens andprogestins. Alternative splicing results in multiple transcript variants encoding the same protein.[10]
KLK5 has been suggested to regulate cell shedding (desquamation) in conjunction withKLK7 andKLK14, given its ability to degrade proteins which form the extracellular component of cell junctions in thestratum corneum. It is proposed that KLK5 regulates this process since it is able to self-activate in addition to activating KLK7 and KLK14.[11]
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^Diamandis EP, Deperthes D, Lundwall Å (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3, 2005".Biological Chemistry.387 (6):635–824.doi:10.1515/BC.2006.081.PMID16800723.S2CID83910246.
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Yousef GM, Scorilas A, Chang A, Rendl L, Diamandis M, Jung K, et al. (May 2002). "Down-regulation of the human kallikrein gene 5 (KLK5) in prostate cancer tissues".The Prostate.51 (2):126–132.doi:10.1002/pros.10067.PMID11948967.S2CID44645840.
Yousef GM, Obiezu CV, Jung K, Stephan C, Scorilas A, Diamandis EP (Oct 2002). "Differential expression of Kallikrein gene 5 in cancerous and normal testicular tissues".Urology.60 (4):714–718.doi:10.1016/S0090-4295(02)01811-3.PMID12385949.
Dong Y, Kaushal A, Brattsand M, Nicklin J, Clements JA (May 2003). "Differential splicing of KLK5 and KLK7 in epithelial ovarian cancer produces novel variants with potential as cancer biomarkers".Clinical Cancer Research.9 (5):1710–1720.PMID12738725.
Yousef GM, Kapadia C, Polymeris ME, Borgono C, Hutchinson S, Wasney GA, et al. (Jul 2003). "The human kallikrein protein 5 (hK5) is enzymatically active, glycosylated and forms complexes with two protease inhibitors in ovarian cancer fluids".Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression.1628 (2):88–96.doi:10.1016/s0167-4781(03)00116-7.PMID12890555.
