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KLK13

From Wikipedia, the free encyclopedia
Gene of the species Homo sapiens

KLK13kmpll
Identifiers
AliasesKLK13, KLK-L4, KLKL4, kallikrein related peptidase 13
External IDsOMIM:605505;MGI:3615275;HomoloGene:56714;GeneCards:KLK13;OMA:KLK13 - orthologs
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[1]
Chromosome 7 (mouse)
Genomic location for KLK13kmpll
Genomic location for KLK13kmpll
Band7|7 B3Start43,361,991bp[1]
End43,376,958bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
    n/a
Top expressed in
  • esophagus

  • lip

  • embryo

  • embryo

  • left lung lobe

  • hair follicle

  • zygote

  • stomach

  • external naris

  • oocyte
BioGPS


More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26085

626834

Ensembl

n/a

ENSMUSG00000054046

UniProt

Q9UKR3
Q5BQ95
Q5BQ97

n/a

RefSeq (mRNA)

NM_015596

NM_001039042

RefSeq (protein)

NP_056411
NP_001335106
NP_001335107

n/a

Location (UCSC)n/aChr 7: 43.36 – 43.38 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Kallikrein-13 is aprotein that in humans is encoded by theKLK13gene.[4][5][6]

Function

[edit]

Kallikreins are a subgroup ofserine proteases having diverse physiological functions.

As of 2022, the precise physiological functions of Kallikrein 13 remain unknown. It may play a role in the defense of the upper digestive apparatus, inextracellular matrix degradation, intissue remodelling, and in the male reproductive organs.

This gene is one of the fifteenkallikrein subfamily members located in a cluster onchromosome 19. Expression of this gene is regulated bysteroid hormones and may be useful as a marker forbreast cancer. An additionaltranscript variant has been identified, but its full length sequence has not been determined.[6]

Kallikrein-13 serves as a priming protease during infection by thehuman coronavirus HKU1.[7]

Many kallikreins are implicated incarcinogenesis and some have potential as novel cancer and other disease biomarkers.

References

[edit]
  1. ^abcGRCm38: Ensembl release 89: ENSMUSG00000054046Ensembl, May 2017
  2. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006)."A comprehensive nomenclature for serine proteases with homology to tissue kallikreins"(PDF).Biol Chem.387 (6):637–41.doi:10.1515/BC.2006.082.PMID 16800724.S2CID 436200.
  5. ^Diamandis EP, Deperthes D, Lundwall Å (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3, 2005".Biol Chem.387 (6):635–824.doi:10.1515/BC.2006.081.PMID 16800723.S2CID 83910246.
  6. ^ab"Entrez Gene: KLK13 kallikrein-related peptidase 13".
  7. ^Milewska A, Falkowski K, Kulczycka M, Bielecka E, Naskalska A, Mak P, Lesner A, Ochman M, Urlik M, Diamandis E, Prassas I, Potempa J, Kantyka T, Pyrc K (2020)."Kallikrein 13 serves as a priming protease during infection by the human coronavirus HKU1".Science Signaling.13 (659): eaba9902.doi:10.1126/scisignal.aba9902.PMC 7857416.PMID 33234691.

Further reading

[edit]

External links

[edit]
  • TheMEROPS online database for peptidases and their inhibitors:S01.306


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