Protein-coding gene in the species Homo sapiens
Krueppel-like factor 5 is aprotein that in humans is encoded by theKLF5 gene .[ 5] [ 6]
This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. Since the protein localizes to the nucleus and binds the epidermal growth factor response element, it is thought to be atranscription factor .[ 6]
KLF5 has been shown tointeract withProtein SET .[ 7]
Clinical significance [ edit ] KLF5 expression has been linked to higher survival rates forlung cancer patients.[ 8]
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World Community Grid. 13 May 2024. Retrieved21 May 2024 .Ghaleb AM, Nandan MO, Chanchevalap S, Dalton WB, Hisamuddin IM, Yang VW (Feb 2005)."Krüppel-like factors 4 and 5: the yin and yang regulators of cellular proliferation" .Cell Research .15 (2):92– 6.doi :10.1038/sj.cr.7290271 .PMC 1317089 PMID 15740636 . Nagai R, Suzuki T, Aizawa K, Shindo T, Manabe I (Aug 2005)."Significance of the transcription factor KLF5 in cardiovascular remodeling" .Journal of Thrombosis and Haemostasis .3 (8):1569– 76.doi :10.1111/j.1538-7836.2005.01366.x PMID 16102021 . McConnell BB, Ghaleb AM, Nandan MO, Yang VW (Jun 2007)."The diverse functions of Krüppel-like factors 4 and 5 in epithelial biology and pathobiology" .BioEssays .29 (6):549– 57.doi :10.1002/bies.20581 .PMC 2211634 PMID 17508399 . 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Hoshino Y, Kurabayashi M, Kanda T, Hasegawa A, Sakamoto H, Okamoto E, Kowase K, Watanabe N, Manabe I, Suzuki T, Nakano A, Takase S, Wilcox JN, Nagai R (Nov 2000)."Regulated expression of the BTEB2 transcription factor in vascular smooth muscle cells: analysis of developmental and pathological expression profiles shows implications as a predictive factor for restenosis" .Circulation .102 (20):2528– 34.doi :10.1161/01.cir.102.20.2528 PMID 11076828 . Sun R, Chen X, Yang VW (Mar 2001)."Intestinal-enriched Krüppel-like factor (Krüppel-like factor 5) is a positive regulator of cellular proliferation" .The Journal of Biological Chemistry .276 (10):6897– 900.doi :10.1074/jbc.C000870200 PMC 2268089 PMID 11152667 . Dang DT, Zhao W, Mahatan CS, Geiman DE, Yang VW (Jul 2002)."Opposing effects of Krüppel-like factor 4 (gut-enriched Krüppel-like factor) and Krüppel-like factor 5 (intestinal-enriched Krüppel-like factor) on the promoter of the Krüppel-like factor 4 gene" .Nucleic Acids Research .30 (13):2736– 41.doi :10.1093/nar/gkf400 .PMC 117055 PMID 12087155 . Shindo T, Manabe I, Fukushima Y, Tobe K, Aizawa K, Miyamoto S, Kawai-Kowase K, Moriyama N, Imai Y, Kawakami H, Nishimatsu H, Ishikawa T, Suzuki T, Morita H, Maemura K, Sata M, Hirata Y, Komukai M, Kagechika H, Kadowaki T, Kurabayashi M, Nagai R (Aug 2002). "Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling".Nature Medicine .8 (8):856– 63.doi :10.1038/nm738 .PMID 12101409 .S2CID 34181151 . Sur I, Undén AB, Toftgård R (Jun 2002). "Human Krüppel-like factor5/KLF5: synergy with NF-kappaB/Rel factors and expression in human skin and hair follicles".European Journal of Cell Biology .81 (6):323– 34.doi :10.1078/0171-9335-00257 .PMID 12113473 . Chen C, Bhalala HV, Qiao H, Dong JT (Sep 2002)."A possible tumor suppressor role of the KLF5 transcription factor in human breast cancer" .Oncogene .21 (43):6567– 72.doi :10.1038/sj.onc.1205817 PMID 12242654 . Yang XO, Doty RT, Hicks JS, Willerford DM (Jun 2003)."Regulation of T-cell receptor D beta 1 promoter by KLF5 through reiterated GC-rich motifs" .Blood .101 (11):4492– 9.doi :10.1182/blood-2002-08-2579 PMID 12576331 . Chen C, Bhalala HV, Vessella RL, Dong JT (May 2003). "KLF5 is frequently deleted and down-regulated but rarely mutated in prostate cancer".The Prostate .55 (2):81– 8.doi :10.1002/pros.10205 .PMID 12661032 .S2CID 21150851 . 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(1) Basic domains
(1.1) Basic leucine zipper (bZIP )(1.2) Basic helix-loop-helix (bHLH )
Group A Group B Group CPAS Group D Group E Group F
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2.1) Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4)β-Scaffold factors with minor groove contacts
(0) Other transcription factors
This article incorporates text from theUnited States National Library of Medicine , which is in thepublic domain .
