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KIF6

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

KIF6

Identifiers

Aliases

KIF6, C6orf102, dJ1043E3.1, dJ137F1.4, dJ188D3.1, kinesin family member 6

External IDs

OMIM:613919;MGI:1098238;HomoloGene:35308;GeneCards:KIF6;OMA:KIF6 - orthologs

Gene location (Human)

Chr.	Chromosome 6 (human)^[1]

Band	6p21.2	Start	39,329,990bp^[1]
Band	6p21.2	End	39,725,408bp^[1]

Gene location (Mouse)

Chr.	Chromosome 17 (mouse)^[2]

Band	17\|17 C	Start	49,922,164bp^[2]
Band	17\|17 C	End	50,216,875bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right uterine tube

corpus callosum

sperm

bronchial epithelial cell

C1 segment

oocyte

olfactory zone of nasal mucosa

testicle

substantia nigra

internal globus pallidus

Top expressed in

otolith organ

utricle

lumbar subsegment of spinal cord

spermatocyte

Rostral migratory stream

tail of embryo

embryo

embryo

lateral ventricle

choroid plexus of lateral ventricle

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	microtubule binding microtubule motor activity nucleotide binding ATPase activity protein binding ATP binding
Cellular component	cytoplasm male germ cell nucleus microtubule cytoskeleton kinesin complex
Biological process	microtubule-based movement
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


221458


319991

Ensembl


ENSG00000164627


ENSMUSG00000023999

UniProt


Q6ZMV9


n/a

RefSeq (mRNA)

NM_001289020 NM_001289021 NM_001289024 NM_145027 NM_001351503
NM_001351566


NM_177052

RefSeq (protein)

NP_001275949 NP_001275950 NP_001275953 NP_659464 NP_001338432
NP_001338495


n/a

Location (UCSC)

Chr 6: 39.33 – 39.73 Mb

Chr 17: 49.92 – 50.22 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Kinesin family member 6 is aprotein that in humans is encoded by the KIF6gene.^[5] This gene encodes a member of thekinesin family of proteins. Members of this family are part of a multisubunit complex that functions as amicrotubule motor in intracellular organelle transport.

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000164627 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000023999 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: Kinesin family member 6".

Koroleva OS, Pushkov AA, Blagodatskikh KA, Baranova OA, Azizova OA, Nosikov VV, Reznichenko NE, Zateĭshchikov DA (2011). "[Association of a polymorphic marker Trp719Arg of KIF6 gene with effects of atorvastatin and simvastatin in patients with early ischemic heart disease]".Kardiologiia.51 (9):4–12.PMID 21943003.
Bare LA, Ruiz-Narvaéz EA, Tong CH, Arellano AR, Rowland CM, Catanese JJ, Sacks FM, Devlin JJ, Campos H (September 2010)."Investigation of KIF6 Trp719Arg in a case-control study of myocardial infarction: a Costa Rican population".PLOS ONE.5 (9) e13081.Bibcode:2010PLoSO...513081B.doi:10.1371/journal.pone.0013081.PMC 2947524.PMID 20927332.
Peng P, Lian J, Huang RS, Xu L, Huang Y, Ba Y, Yang X, Huang X, Dong C, Zhang L, Ye M, Zhou J, Duan S (2012)."Meta-analyses of KIF6 Trp719Arg in coronary heart disease and statin therapeutic effect".PLOS ONE.7 (12) e50126.Bibcode:2012PLoSO...750126P.doi:10.1371/journal.pone.0050126.PMC 3517591.PMID 23236363.
Akao H, Polisecki E, Kajinami K, Trompet S, Robertson M, Ford I, Jukema JW, de Craen AJ, Westendorp RG, Shepherd J, Packard C, Buckley BM, Schaefer EJ (February 2012). "KIF6, LPA, TAS2R50, and VAMP8 genetic variation, low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly".Atherosclerosis.220 (2):456–62.doi:10.1016/j.atherosclerosis.2011.11.037.PMID 22192511.
Liu X, Gomez-Pinillos A, Loder C, Carrillo-de Santa Pau E, Qiao R, Unger PD, Kurek R, Oddoux C, Melamed J, Gallagher RE, Mandeli J, Ferrari AC (September 2012)."KLF6 loss of function in human prostate cancer progression is implicated in resistance to androgen deprivation".The American Journal of Pathology.181 (3):1007–16.doi:10.1016/j.ajpath.2012.06.008.PMC 3432435.PMID 22819534.
Davani S, Gozalo C, Gambert S, Chalmers D, Gambert P, Schiele F, Kantelip JP, Meneveau N (May 2010). "The polymorphism Trp719Arg in the kinesin-like protein 6 is associated with the presence of late outgrowth endothelial progenitor cells in acute myocardial infarction".Atherosclerosis.210 (1):48–50.doi:10.1016/j.atherosclerosis.2009.11.041.PMID 20044086.
Hu M, Lui SS, Mak VW, Chu TT, Lee VW, Poon EW, Tsui TK, Ko GT, Baum L, Tam LS, Li EK, Tomlinson B (October 2010). "Pharmacogenetic analysis of lipid responses to rosuvastatin in Chinese patients".Pharmacogenetics and Genomics.20 (10):634–7.doi:10.1097/FPC.0b013e32833de489.PMID 20679960.S2CID 3475599.
Koroleva OS, Zateĭshchikov DA (2010). "[Motor protein Kinesin-6 and ischemic heart disease]".Kardiologiia.50 (6):54–62.PMID 20659029.
Bhanushali AA, Contractor A, Shah VT, Das BR (December 2011). "Investigation of KIF6 Trp719Arg in a case-control study of coronary artery disease in Western Indians".Genetic Testing and Molecular Biomarkers.15 (12):883–6.doi:10.1089/gtmb.2011.0079.PMID 21810021.

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Proteins of thecytoskeleton

Human

Microfilaments
andABPs

Myofilament

Actins	A1 A2 B C1 G1 G2
Myosins	I MYO1A MYO1B MYO1C MYO1D MYO1E MYO1F MYO1G MYO1H) II MYH1 MYH2 MYH3 MYH4 MYH6 MYH7 MYH7B MYH8 MYH9 MYH10 MYH11 MYH13 MYH14 MYH15 MYH16 III MYO3A MYO3B V MYO5A MYO5B MYO5C VI MYO6 VII MYO7A MYO7B IX MYO9A MYO9B X MYO10 XV MYO15A XVIII MYO18A MYO18B LC MYL1 MYL2 MYL3 MYL4 MYL5 MYL6 MYL6B MYL7 MYL9 MYLIP MYLK MYLK2 MYLL1
Other	Tropomodulin 1 2 3 4 Troponin T 1 2 3 C 1 2 I 1 2 3 Tropomyosin 1 2 3 4 Actinin 1 2 3 4 Arp2/3 complex actin depolymerizing factors Cofilin 1 2 Destrin Gelsolin Profilin 1 2 Titin

Other

Intermediate
filaments

Type 1/2
(Keratin,
Cytokeratin)

Epithelial keratins (soft alpha-keratins)	type I/chromosome 17 9 10 12 13 14 15 16 17 19 20 chromosome 12 18 none 21 type II/chromosome 12 1 2A 3 4 5 6A 6B 6C 7 8
Hair keratins (hard alpha-keratins)	type I/chromosome 17 31 32 33A 33B 34 35 36 37 38 type II/chromosome 12 81 82 83 84 85 86
Ungrouped alpha	chromosome 17 23 24 25 26 27 28 39 40 chromosome 12 71 72 73 74 75 76 77 78 79 80
Not alpha	Beta-keratin

Type 3

Type 4

Type 5

Microtubules
andMAPs

Tubulins	TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA8 TUBB TUBB1 TUBB2A TUBB2B TUBB2C TUBB3 TUBB4 TUBB4Q TUBB6 TUBB8 TUBG1 TUBG2 TUBGCP2 TUBGCP3 TUBGCP4 TUBGCP5 TUBGCP6 TUBD1 TUBE1
MAPs	EB1 EB2 EB3 MAP1A MAP1B MAP2 MAP4
Kinesins	KIF1A KIF1B KIF2A KIF2C KIF3B KIF3C KIF4A KIF4B KIF5A KIF5B KIF5C KIF6 KIF7 KIF9 KIF11 KIF12 KIF13A KIF13B KIF14 KIF15 KIF16B KIF17 KIF18A KIF18B KIF19 KIF20A KIF20B KIF21A KIF21B KIF22 KIF23 KIF24 KIF25 KIF26A KIF26B KIF27 KIFC1 KIFC2 KIFC3
Dyneins	axonemal:DNAH1 DNAH2 DNAH3 DNAH5 DNAH6 DNAH7 DNAH8 DNAH9 DNAH10 DNAH11 DNAH12 DNAH13 DNAH14 DNAH17 DNAI1 DNAI2 DNALI1 DNAL1 DNAL4 cytoplasmic:DYNC1H1 DYNC2H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC2LI1 DYNLL1 DYNLL2 DYNLRB1 DYNLRB2 DYNLT1 DYNLT3
Microtubule organising proteins	CAMSAP1 CAMSAP2 CAMSAP3 Centrin 1 Centrin 2 Centrin 3 PCM1
Microtubule severing proteins	Katanin Spastin
Other	Tau protein Dynactin DCTN1 Stathmin Tektin TEKT1 TEKT2 TEKT3 TEKT4 TEKT5 Dynamin DNM1 DNM2 DNM3

Catenins

Membrane

Other

Nonhuman

See also:cytoskeletal defects

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