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KIF1B

From Wikipedia, the free encyclopedia

Mammalian protein found in Homo sapiens

KIF1B

Available structures

Ortholog search:PDBe RCSB

List of PDB id codes
2EH0

Identifiers

KIF1B, CMT2, CMT2A, CMT2A1, HMSNII, KLP, NBLST1, kinesin family member 1B

External IDs

OMIM:605995;MGI:108426;HomoloGene:99835;GeneCards:KIF1B;OMA:KIF1B - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1p36.22	Start	10,210,570bp^[1]
Band	1p36.22	End	10,381,603bp^[1]

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)^[2]

Band	4 E2\|4 79.05 cM	Start	149,260,776bp^[2]
Band	4 E2\|4 79.05 cM	End	149,392,150bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

Skeletal muscle tissue of rectus abdominis

biceps brachii

internal globus pallidus

Brodmann area 46

Skeletal muscle tissue of biceps brachii

middle temporal gyrus

ventricular zone

pars reticulata

Region I of hippocampus proper

pars compacta

Top expressed in

retinal pigment epithelium

neural layer of retina

pontine nuclei

dorsal tegmental nucleus

ventral tegmental area

habenula

globus pallidus

subiculum

deep cerebellar nuclei

dorsomedial hypothalamic nucleus

More reference expression data

n/a

Gene ontology
Molecular function	microtubule motor activity nucleotide binding microtubule binding ATPase activity protein binding kinesin binding ATP binding kinase binding scaffold protein binding plus-end-directed microtubule motor activity
Cellular component	cytoplasm kinesin complex microtubule associated complex mitochondrion neuron projection microtubule cytoskeleton cytoplasmic vesicle membrane cytoplasmic vesicle axon cytoplasm membrane axon dendrite
Biological process	cytoskeleton-dependent intracellular transport neuron-neuron synaptic transmission anterograde axonal transport microtubule-based movement neuromuscular synaptic transmission mitochondrion transport along microtubule apoptotic process positive regulation of gene expression transport along microtubule lysosome localization response to rotenone cellular response to nerve growth factor stimulus protein localization to cell periphery anterograde neuronal dense core vesicle transport retrograde neuronal dense core vesicle transport vesicle-mediated transport
Sources:Amigo /QuickGO

Species

Human

Mouse


23095


16561


ENSG00000054523


ENSMUSG00000063077


O60333


Q60575

RefSeq (mRNA)


NM_183416 NM_015074 NM_001365951 NM_001365952 NM_001365953


NM_001290995 NM_008441 NM_207682

RefSeq (protein)


NP_055889 NP_904325 NP_001352880 NP_001352881 NP_001352882


NP_001277924 NP_032467 NP_997565

Location (UCSC)

Chr 1: 10.21 – 10.38 Mb

Chr 4: 149.26 – 149.39 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Kinesin-like protein KIF1B is aprotein that in humans is encoded by theKIF1Bgene.^[5]^[6]^[7]

Clinical significance

It is associated withCharcot–Marie–Tooth disease, type 2A1.^[7]

Interactions

KIF1B has been shown tointeract withGIPC1.^[8]

References

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000054523 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000063077 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Zhao C, Takita J, Tanaka Y, Setou M, Nakagawa T, Takeda S, Yang HW, Terada S, Nakata T, Takei Y, Saito M, Tsuji S, Hayashi Y, Hirokawa N (June 2001)."Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta".Cell.105 (5):587–97.doi:10.1016/S0092-8674(01)00363-4.PMID 11389829.S2CID 17303998.
^Nagai M, Ichimiya S, Ozaki T, Seki N, Mihara M, Furuta S, Ohira M, Tomioka N, Nomura N, Sakiyama S, Kubo O, Takakura K, Hori T, Nakagawara A (May 2000). "Identification of the full-length KIAA0591 gene encoding a novel kinesin-related protein which is mapped to the neuroblastoma suppressor gene locus at 1p36.2".Int J Oncol.16 (5):907–16.doi:10.3892/ijo.16.5.907.PMID 10762626.
^^a ^b"Entrez Gene: KIF1B kinesin family member 1B".
^Bunn RC, Jensen M A, Reed B C (April 1999)."Protein Interactions with the Glucose Transporter Binding Protein GLUT1CBP That Provide a Link between GLUT1 and the Cytoskeleton".Mol. Biol. Cell.10 (4):819–32.doi:10.1091/mbc.10.4.819.ISSN 1059-1524.PMC 25204.PMID 10198040.

Further reading

Nangaku M, Sato-Yoshitake R, Okada Y, et al. (1995). "KIF1B, a novel microtubule plus end-directed monomeric motor protein for transport of mitochondria".Cell.79 (7):1209–20.doi:10.1016/0092-8674(94)90012-4.PMID 7528108.S2CID 38430180.
Gong TL, Burmeister M, Lomax MI (1997). "The novel gene D4Mil1e maps to mouse chromosome 4 and human chromosome 1p36".Mamm. Genome.7 (10):790–1.doi:10.1007/s003359900237.PMID 8854876.S2CID 40174732.
Saito M, Hayashi Y, Suzuki T, et al. (1998). "Linkage mapping of the gene for Charcot-Marie-Tooth disease type 2 to chromosome 1p (CMT2A) and the clinical features of CMT2A".Neurology.49 (6):1630–5.doi:10.1212/wnl.49.6.1630.PMID 9409358.S2CID 32002103.
Nagase T, Ishikawa K, Miyajima N, et al. (1998)."Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro".DNA Res.5 (1):31–9.doi:10.1093/dnares/5.1.31.PMID 9628581.
Bunn RC, Jensen MA, Reed BC (1999)."Protein Interactions with the Glucose Transporter Binding Protein GLUT1CBP That Provide a Link between GLUT1 and the Cytoskeleton".Mol. Biol. Cell.10 (4):819–32.doi:10.1091/mbc.10.4.819.PMC 25204.PMID 10198040.
Conforti L, Buckmaster EA, Tarlton A, et al. (1999). "The major brain isoform of kif1b lacks the putative mitochondria-binding domain".Mamm. Genome.10 (6):617–22.doi:10.1007/s003359901056.PMID 10341097.S2CID 24223913.
Nagase T, Kikuno R, Ishikawa K, et al. (2000)."Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro".DNA Res.7 (2):143–50.doi:10.1093/dnares/7.2.143.PMID 10819331.
Yang HW, Chen YZ, Takita J, et al. (2001). "Genomic structure and mutational analysis of the human KIF1B gene which is homozygously deleted in neuroblastoma at chromosome 1p36.2".Oncogene.20 (36):5075–83.doi:10.1038/sj.onc.1204456.PMID 11526494.S2CID 20404213.
Mok H, Shin H, Kim S, et al. (2002)."Association of the kinesin superfamily motor protein KIF1Balpha with postsynaptic density-95 (PSD-95), synapse-associated protein-97, and synaptic scaffolding molecule PSD-95/discs large/zona occludens-1 proteins".J. Neurosci.22 (13):5253–8.doi:10.1523/JNEUROSCI.22-13-05253.2002.PMC 6758229.PMID 12097473.
Nakamura N, Miyake Y, Matsushita M, et al. (2003)."KIF1Bbeta2, capable of interacting with CHP, is localized to synaptic vesicles".J. Biochem.132 (3):483–91.doi:10.1093/oxfordjournals.jbchem.a003246.PMID 12204119.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26):16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.
Huang YS, Carson JH, Barbarese E, Richter JD (2003)."Facilitation of dendritic mRNA transport by CPEB".Genes Dev.17 (5):638–53.doi:10.1101/gad.1053003.PMC 196011.PMID 12629046.
Chen YY, Takita J, Chen YZ, et al. (2004). "Genomic structure and mutational analysis of the human KIF1Balpha gene located at 1p36.2 in neuroblastoma".Int. J. Oncol.23 (3):737–44.doi:10.3892/ijo.23.3.737.PMID 12888911.
Rodriguez M, Yu X, Chen J, Songyang Z (2004)."Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains".J. Biol. Chem.278 (52):52914–8.doi:10.1074/jbc.C300407200.PMID 14578343.
Nagaraja GM, Kandpal RP (2004). "Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins".Biochem. Biophys. Res. Commun.313 (3):654–65.doi:10.1016/j.bbrc.2003.12.001.PMID 14697242.
Ota T, Suzuki Y, Nishikawa T, et al. (2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs".Nat. Genet.36 (1):40–5.doi:10.1038/ng1285.PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004)."Large-scale characterization of HeLa cell nuclear phosphoproteins".Proc. Natl. Acad. Sci. U.S.A.101 (33):12130–5.Bibcode:2004PNAS..10112130B.doi:10.1073/pnas.0404720101.PMC 514446.PMID 15302935.
Jin J, Smith FD, Stark C, et al. (2004)."Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization".Curr. Biol.14 (16):1436–50.Bibcode:2004CBio...14.1436J.doi:10.1016/j.cub.2004.07.051.PMID 15324660.S2CID 2371325.

External links

GeneReviews/NCBI/NIH/UW entry on Charcot-Marie-Tooth Neuropathy Type 2

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Proteins of thecytoskeleton

Human

Microfilaments
andABPs

Actins	A1 A2 B C1 G1 G2
Myosins	I MYO1A MYO1B MYO1C MYO1D MYO1E MYO1F MYO1G MYO1H) II MYH1 MYH2 MYH3 MYH4 MYH6 MYH7 MYH7B MYH8 MYH9 MYH10 MYH11 MYH13 MYH14 MYH15 MYH16 III MYO3A MYO3B V MYO5A MYO5B MYO5C VI MYO6 VII MYO7A MYO7B IX MYO9A MYO9B X MYO10 XV MYO15A XVIII MYO18A MYO18B LC MYL1 MYL2 MYL3 MYL4 MYL5 MYL6 MYL6B MYL7 MYL9 MYLIP MYLK MYLK2 MYLL1
Other	Tropomodulin 1 2 3 4 Troponin T 1 2 3 C 1 2 I 1 2 3 Tropomyosin 1 2 3 4 Actinin 1 2 3 4 Arp2/3 complex actin depolymerizing factors Cofilin 1 2 Destrin Gelsolin Profilin 1 2 Titin

Other

Intermediate
filaments

Type 1/2
(Keratin,
Cytokeratin)

Epithelial keratins (soft alpha-keratins)	type I/chromosome 17 9 10 12 13 14 15 16 17 19 20 chromosome 12 18 none 21 type II/chromosome 12 1 2A 3 4 5 6A 6B 6C 7 8
Hair keratins (hard alpha-keratins)	type I/chromosome 17 31 32 33A 33B 34 35 36 37 38 type II/chromosome 12 81 82 83 84 85 86
Ungrouped alpha	chromosome 17 23 24 25 26 27 28 39 40 chromosome 12 71 72 73 74 75 76 77 78 79 80
Not alpha	Beta-keratin

Type 3

Type 4

Type 5

Microtubules
andMAPs

Tubulins	TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA8 TUBB TUBB1 TUBB2A TUBB2B TUBB2C TUBB3 TUBB4 TUBB4Q TUBB6 TUBB8 TUBG1 TUBG2 TUBGCP2 TUBGCP3 TUBGCP4 TUBGCP5 TUBGCP6 TUBD1 TUBE1
MAPs	EB1 EB2 EB3 MAP1A MAP1B MAP2 MAP4
Kinesins	KIF1A KIF1B KIF2A KIF2C KIF3B KIF3C KIF4A KIF4B KIF5A KIF5B KIF5C KIF6 KIF7 KIF9 KIF11 KIF12 KIF13A KIF13B KIF14 KIF15 KIF16B KIF17 KIF18A KIF18B KIF19 KIF20A KIF20B KIF21A KIF21B KIF22 KIF23 KIF24 KIF25 KIF26A KIF26B KIF27 KIFC1 KIFC2 KIFC3
Dyneins	axonemal:DNAH1 DNAH2 DNAH3 DNAH5 DNAH6 DNAH7 DNAH8 DNAH9 DNAH10 DNAH11 DNAH12 DNAH13 DNAH14 DNAH17 DNAI1 DNAI2 DNALI1 DNAL1 DNAL4 cytoplasmic:DYNC1H1 DYNC2H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC2LI1 DYNLL1 DYNLL2 DYNLRB1 DYNLRB2 DYNLT1 DYNLT3
Microtubule organising proteins	CAMSAP1 CAMSAP2 CAMSAP3 Centrin 1 Centrin 2 Centrin 3 PCM1
Microtubule severing proteins	Katanin Spastin
Other	Tau protein Dynactin DCTN1 Stathmin Tektin TEKT1 TEKT2 TEKT3 TEKT4 TEKT5 Dynamin DNM1 DNM2 DNM3

Other

Nonhuman

See also:cytoskeletal defects

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