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KIF14

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

KIF14

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
4OZQ

Identifiers

Aliases

KIF14, MKS12, kinesin family member 14, MCPH20

External IDs

OMIM:611279;MGI:1098226;HomoloGene:8916;GeneCards:KIF14;OMA:KIF14 - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1q32.1	Start	200,551,497bp^[1]
Band	1q32.1	End	200,620,751bp^[1]

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)^[2]

Band	1 E4\|1 59.8 cM	Start	136,394,081bp^[2]
Band	1 E4\|1 59.8 cM	End	136,459,249bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

secondary oocyte

trabecular bone

gonad

ventricular zone

buccal mucosa cell

testicle

embryo

bone marrow

thymus

ganglionic eminence

Top expressed in

zygote

tail of embryo

genital tubercle

secondary oocyte

spermatocyte

ventricular zone

spermatid

yolk sac

blastocyst

embryo

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	tubulin binding nucleotide binding protein kinase binding plus-end-directed microtubule motor activity PDZ domain binding microtubule motor activity microtubule binding ATP binding protein binding ATPase activity
Cellular component	spindle cytoplasm kinesin complex nucleus membrane midbody microtubule plasma membrane spindle midzone cytoskeleton cytosol Flemming body
Biological process	negative regulation of integrin activation cerebral cortex development negative regulation of apoptotic process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process regulation of neuron apoptotic process hippocampus development regulation of cell growth cell division substrate adhesion-dependent cell spreading regulation of G1/S transition of mitotic cell cycle cell proliferation in forebrain regulation of G2/M transition of mitotic cell cycle cerebellar granular layer structural organization olfactory bulb development microtubule depolymerization proteasome-mediated ubiquitin-dependent protein catabolic process cerebellar Purkinje cell layer structural organization regulation of myelination positive regulation of cell population proliferation regulation of Rap protein signal transduction cerebellar cortex development positive regulation of cytokinesis negative regulation of neuron apoptotic process establishment of protein localization regulation of cell migration mitotic metaphase plate congression regulation of cell maturation microtubule-based movement activation of protein kinase activity regulation of cell adhesion
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


9928


381293

Ensembl


ENSG00000118193


ENSMUSG00000041498

UniProt


Q15058


L0N7N1

RefSeq (mRNA)


NM_001305792 NM_014875


NM_001081258 NM_001287179

RefSeq (protein)


NP_001292721 NP_055690


NP_001274108

Location (UCSC)

Chr 1: 200.55 – 200.62 Mb

Chr 1: 136.39 – 136.46 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Kinesin-like protein KIF14 is aprotein that in humans is encoded by theKIF14gene.^[5]^[6]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000118193 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000041498 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (Dec 1995)."Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1".DNA Res.1 (5):223–9.doi:10.1093/dnares/1.5.223.PMID 7584044.
^"Entrez Gene: KIF14 kinesin family member 14".

Nakagawa T, Tanaka Y, Matsuoka E, et al. (1997)."Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome".Proc. Natl. Acad. Sci. U.S.A.94 (18):9654–9.Bibcode:1997PNAS...94.9654N.doi:10.1073/pnas.94.18.9654.PMC 23244.PMID 9275178.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26):16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.
Corson TW, Huang A, Tsao MS, Gallie BL (2005)."KIF14 is a candidate oncogene in the 1q minimal region of genomic gain in multiple cancers".Oncogene.24 (30):4741–53.doi:10.1038/sj.onc.1208641.PMID 15897902.
Gruneberg U, Neef R, Li X, et al. (2006)."KIF14 and citron kinase act together to promote efficient cytokinesis".J. Cell Biol.172 (3):363–72.doi:10.1083/jcb.200511061.PMC 2063646.PMID 16431929.
Corson TW, Gallie BL (2006)."KIF14 mRNA expression is a predictor of grade and outcome in breast cancer".Int. J. Cancer.119 (5):1088–94.doi:10.1002/ijc.21954.PMID 16570270.
Carleton M, Mao M, Biery M, et al. (2006)."RNA interference-mediated silencing of mitotic kinesin KIF14 disrupts cell cycle progression and induces cytokinesis failure".Mol. Cell. Biol.26 (10):3853–63.doi:10.1128/MCB.26.10.3853-3863.2006.PMC 1488988.PMID 16648480.
Olsen JV, Blagoev B, Gnad F, et al. (2006)."Global, in vivo, and site-specific phosphorylation dynamics in signaling networks".Cell.127 (3):635–48.doi:10.1016/j.cell.2006.09.026.PMID 17081983.S2CID 7827573.
Bowles E, Corson TW, Bayani J, et al. (2007). "Profiling genomic copy number changes in retinoblastoma beyond loss of RB1".Genes Chromosomes Cancer.46 (2):118–29.doi:10.1002/gcc.20383.PMID 17099872.S2CID 22499766.
Vasilescu J, Zweitzig DR, Denis NJ, et al. (2007). "The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells".J. Proteome Res.6 (1):298–305.CiteSeerX 10.1.1.401.4220.doi:10.1021/pr060438j.PMID 17203973.
Corson TW, Zhu CQ, Lau SK, et al. (2007)."KIF14 messenger RNA expression is independently prognostic for outcome in lung cancer".Clin. Cancer Res.13 (11):3229–34.doi:10.1158/1078-0432.CCR-07-0393.PMID 17545527.
Madhavan J, Coral K, Mallikarjuna K, et al. (2007)."High expression of KIF14 in retinoblastoma: association with older age at diagnosis".Invest. Ophthalmol. Vis. Sci.48 (11):4901–6.doi:10.1167/iovs.07-0063.PMID 17962437.

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