Lysine-specific demethylase 5C is anenzyme that in humans is encoded by theKDM5Cgene.[5][6][7] KDM5C belongs to thealpha-ketoglutarate-dependent hydroxylase superfamily.
This gene is a member of the SMCY homolog family and encodes a protein with oneARID domain, one JmjC domain, one JmjN domain and twoPHD-type zinc fingers. The DNA-binding motif suggest this protein is involved in the regulation of transcription and chromatin remodeling. Mutations in this gene have been associated withX-linked intellectual disability. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.[7]
This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.
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