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KCNV2

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

KCNV2

Identifiers

Aliases

KCNV2, KV11.1, Kv8.2, RCD3B, potassium voltage-gated channel modifier subfamily V member 2

External IDs

OMIM:607604;MGI:2670981;HomoloGene:26423;GeneCards:KCNV2;OMA:KCNV2 - orthologs

Gene location (Human)

Chr.	Chromosome 9 (human)^[1]

Band	9p24.2	Start	2,717,510bp^[1]
Band	9p24.2	End	2,730,037bp^[1]

Gene location (Mouse)

Chr.	Chromosome 19 (mouse)^[2]

Band	19\|19 C1	Start	27,299,988bp^[2]
Band	19\|19 C1	End	27,314,579bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

sperm

testicle

gonad

retinal pigment epithelium

right testis

left testis

sural nerve

pancreatic ductal cell

right hemisphere of cerebellum

ganglionic eminence

Top expressed in

neural layer of retina

outer nuclear layer

embryo

blastocyst

gastrula

lumbar subsegment of spinal cord

inner nuclear layer

zygote

lumbar spinal ganglion

sternocleidomastoid muscle

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	ion channel activity potassium channel activity voltage-gated ion channel activity voltage-gated potassium channel activity
Cellular component	integral component of membrane voltage-gated potassium channel complex plasma membrane membrane
Biological process	potassium ion transport regulation of ion transmembrane transport protein homooligomerization ion transport transmembrane transport potassium ion transmembrane transport
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


169522


240595

Ensembl


ENSG00000168263


ENSMUSG00000047298

UniProt


Q8TDN2


Q8CFS6

RefSeq (mRNA)


NM_133497


NM_183179

RefSeq (protein)


NP_598004


NP_899002

Location (UCSC)

Chr 9: 2.72 – 2.73 Mb

Chr 19: 27.3 – 27.31 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Potassium voltage-gated channel subfamily V member 2 is aprotein that in humans is encoded by theKCNV2gene.^[5]^[6] Theprotein encoded by this gene is avoltage-gated potassium channel subunit.^[5]^[6]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000168263 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000047298 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^^a ^bOttschytsch N, Raes A, Van Hoorick D, Snyders DJ (Jun 2002)."Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome".Proc Natl Acad Sci U S A.99 (12):7986–91.Bibcode:2002PNAS...99.7986O.doi:10.1073/pnas.122617999.PMC 123007.PMID 12060745.
^^a ^bGutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels".Pharmacol Rev.57 (4):473–508.doi:10.1124/pr.57.4.10.PMID 16382104.S2CID 219195192.

External links

[edit]

Kv8.2+Potassium+Channel at the U.S. National Library of MedicineMedical Subject Headings (MeSH)
KCNV2+protein,+human at the U.S. National Library of MedicineMedical Subject Headings (MeSH)

Membrane transport protein:ion channels (TC 1A)

Ca²⁺:Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺:Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺:Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻:Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺:Proton channel	HVCN1
M⁺:CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺:TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+solutes):Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm:Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin

By gating mechanism

Ion channel class	Ligand-gated Light-gated Voltage-gated Stretch-activated

see alsodisorders

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