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KCNK1

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

KCNK1

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
3UKM

Identifiers

Aliases

KCNK1, DPK, HOHO, K2P1, K2p1.1, KCNO1, TWIK-1, TWIK1, potassium two pore domain channel subfamily K member 1

External IDs

OMIM:601745;MGI:109322;HomoloGene:1691;GeneCards:KCNK1;OMA:KCNK1 - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1q42.2	Start	233,614,106bp^[1]
Band	1q42.2	End	233,672,514bp^[1]

Gene location (Mouse)

Chr.	Chromosome 8 (mouse)^[2]

Band	8\|8 E2	Start	126,721,909bp^[2]
Band	8\|8 E2	End	126,757,424bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

cerebellar vermis

pons

endothelial cell

cerebellar hemisphere

orbitofrontal cortex

right hemisphere of cerebellum

paraflocculus of cerebellum

cartilage tissue

corpus epididymis

cardiac muscle tissue of right atrium

Top expressed in

seminal vesicula

molar

choroid plexus of fourth ventricle

lobe of cerebellum

lobe of prostate

mucosa of urinary bladder

transitional epithelium of urinary bladder

cerebellar vermis

Epithelium of choroid plexus

submandibular gland

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	sodium channel activity potassium ion leak channel activity voltage-gated potassium channel activity inward rectifier potassium channel activity potassium channel activity protein binding identical protein binding
Cellular component	cytoplasm integral component of membrane recycling endosome perikaryon endosome cell projection membrane voltage-gated potassium channel complex plasma membrane integral component of plasma membrane synapse inward rectifier potassium channel complex brush border membrane cell junction dendrite potassium channel complex apical plasma membrane cytoplasmic vesicle intracellular membrane-bounded organelle
Biological process	sodium ion transmembrane transport response to nicotine ion transport potassium ion transport cardiac conduction potassium ion transmembrane transport regulation of resting membrane potential stabilization of membrane potential
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


3775


16525

Ensembl


ENSG00000135750


ENSMUSG00000033998

UniProt


O00180


O08581

RefSeq (mRNA)


NM_002245


NM_008430

RefSeq (protein)


NP_002236


NP_032456

Location (UCSC)

Chr 1: 233.61 – 233.67 Mb

Chr 8: 126.72 – 126.76 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Potassium channel subfamily K member 1 is aprotein that in humans is encoded by theKCNK1gene.^[5]^[6]^[7]

This gene encodes K_2P1.1, a member of the superfamily ofpotassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, and it may require other non-pore-forming proteins for activity.^[7]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000135750 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000033998 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Lesage F, Mattei M, Fink M, Barhanin J, Lazdunski M (Dec 1996). "Assignment of the human weak inward rectifier K+ channel TWIK-1 gene to chromosome 1q42-q43".Genomics.34 (1):153–5.doi:10.1006/geno.1996.0259.PMID 8661042.
^Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005)."International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels".Pharmacol Rev.57 (4):527–40.doi:10.1124/pr.57.4.12.PMID 16382106.S2CID 7356601.
^^a ^b"Entrez Gene: KCNK1 potassium channel, subfamily K, member 1".

External links

[edit]

KCNK1+protein,+human at the U.S. National Library of MedicineMedical Subject Headings (MeSH)

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

Membrane transport protein:ion channels (TC 1A)

Ca²⁺:Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺:Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺:Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻:Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺:Proton channel	HVCN1
M⁺:CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺:TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+solutes):Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm:Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin