G protein-activated inward rectifier potassium channel 1(GIRK-1) is encoded in the human by the geneKCNJ3.[5]
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a hetero-tetrameric pore-forming complex.[5]
Kubo Y, Adelman JP, Clapham DE, et al. (2006). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels".Pharmacol. Rev.57 (4):509–26.doi:10.1124/pr.57.4.11.PMID16382105.S2CID11588492.
Stoffel M, Espinosa R, Powell KL, et al. (1994). "Human G-protein-coupled inwardly rectifying potassium channel (GIRK1) gene (KCNJ3): localization to chromosome 2 and identification of a simple tandem repeat polymorphism".Genomics.21 (1):254–6.doi:10.1006/geno.1994.1253.PMID8088798.
Schoots O, Yue KT, MacDonald JF, et al. (1996). "Cloning of a G protein-activated inwardly rectifying potassium channel from human cerebellum".Brain Res. Mol. Brain Res.39 (1–2):23–30.doi:10.1016/0169-328X(95)00349-W.PMID8804710.
Schoots O, Voskoglou T, Van Tol HH (1997). "Genomic organization and promoter analysis of the human G-protein-coupled K+ channel Kir3.1 (KCNJ3/HGIRK1)".Genomics.39 (3):279–88.doi:10.1006/geno.1996.4495.PMID9119365.
