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KCNH7

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

KCNH7

Identifiers

Aliases

KCNH7, ERG3, HERG3, Kv11.3, potassium voltage-gated channel subfamily H member 7

External IDs

OMIM:608169;MGI:2159566;HomoloGene:13249;GeneCards:KCNH7;OMA:KCNH7 - orthologs

Gene location (Human)

Chr.	Chromosome 2 (human)^[1]

Band	2q24.2	Start	162,371,407bp^[1]
Band	2q24.2	End	162,838,767bp^[1]

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	2\|2 C1.3	Start	62,523,758bp^[2]
Band	2\|2 C1.3	End	63,014,631bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

testicle

pancreatic ductal cell

ventricular zone

ganglionic eminence

tibialis anterior muscle

islet of Langerhans

prefrontal cortex

mucosa of ileum

blood

corpus callosum

Top expressed in

primary visual cortex

superior frontal gyrus

ventricular zone

molecular layer of cerebellar cortex

granulocyte

embryo

dentate gyrus of hippocampal formation granule cell

granular layer

primary motor cortex

Purkinje cell

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	voltage-gated ion channel activity ion channel activity voltage-gated potassium channel activity potassium channel activity
Cellular component	plasma membrane membrane integral component of membrane integral component of plasma membrane
Biological process	ion transport transmembrane transport potassium ion transmembrane transport potassium ion transport regulation of membrane potential regulation of ion transmembrane transport
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


90134


170738

Ensembl


ENSG00000184611


ENSMUSG00000059742

UniProt


Q9NS40


Q9ER47

RefSeq (mRNA)


NM_033272 NM_173162


NM_133207

RefSeq (protein)


NP_150375 NP_775185


NP_573470

Location (UCSC)

Chr 2: 162.37 – 162.84 Mb

Chr 2: 62.52 – 63.01 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Potassium voltage-gated channel subfamily H member 7 is aprotein that in humans is encoded by theKCNH7gene.^[5] Theprotein encoded by this gene is avoltage-gated potassium channel subunit.^[5]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000184611 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000059742 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^^a ^bGutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels".Pharmacol Rev.57 (4):473–508.doi:10.1124/pr.57.4.10.PMID 16382104.S2CID 219195192.

External links

[edit]

Kv11.3+Potassium+Channel at the U.S. National Library of MedicineMedical Subject Headings (MeSH)
KCNH7+protein,+human at the U.S. National Library of MedicineMedical Subject Headings (MeSH)

Membrane transport protein:ion channels (TC 1A)

Ca²⁺:Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺:Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺:Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻:Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺:Proton channel	HVCN1
M⁺:CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺:TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+solutes):Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm:Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin

By gating mechanism

Ion channel class	Ligand-gated Light-gated Voltage-gated Stretch-activated

see alsodisorders

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