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KCNG3

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

KCNG3

Identifiers

Aliases

KCNG3, KV10.1, KV6.3, potassium voltage-gated channel modifier subfamily G member 3

External IDs

OMIM:606767;MGI:2663923;HomoloGene:15168;GeneCards:KCNG3;OMA:KCNG3 - orthologs

Gene location (Human)

Chr.	Chromosome 2 (human)^[1]

Band	2p21	Start	42,442,017bp^[1]
Band	2p21	End	42,493,982bp^[1]

Gene location (Mouse)

Chr.	Chromosome 17 (mouse)^[2]

Band	17\|17 E4	Start	83,893,386bp^[2]
Band	17\|17 E4	End	83,939,324bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

islet of Langerhans

prefrontal cortex

right adrenal gland

left adrenal gland

right adrenal cortex

middle temporal gyrus

endometrium

left adrenal cortex

Brodmann area 23

entorhinal cortex

Top expressed in

secondary oocyte

zygote

primary oocyte

epiblast

dentate gyrus of hippocampal formation granule cell

embryo

adrenal gland

hippocampus proper

ovary

Cortex of frontal lobe

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	voltage-gated potassium channel activity ion channel activity potassium channel activity protein binding delayed rectifier potassium channel activity voltage-gated ion channel activity
Cellular component	cytoplasm integral component of membrane voltage-gated potassium channel complex plasma membrane endoplasmic reticulum membrane
Biological process	potassium ion transport regulation of ion transmembrane transport protein homooligomerization ion transport transmembrane transport potassium ion transmembrane transport
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


170850


225030

Ensembl


ENSG00000171126


ENSMUSG00000045053

UniProt


Q8TAE7


P59053

RefSeq (mRNA)


NM_172344 NM_133329


NM_153512

RefSeq (protein)


NP_579875 NP_758847


NP_705732

Location (UCSC)

Chr 2: 42.44 – 42.49 Mb

Chr 17: 83.89 – 83.94 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Potassium voltage-gated channel subfamily G member 3 is aprotein that in humans is encoded by theKCNG3gene.^[5]^[6] Theprotein encoded by this gene is avoltage-gated potassium channel subunit.^[6]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000171126 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000045053 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Sano Y, Mochizuki S, Miyake A, Kitada C, Inamura K, Yokoi H, Nozawa K, Matsushime H, Furuichi K (Feb 2002)."Molecular cloning and characterization of Kv6.3, a novel modulatory subunit for voltage-gated K(+) channel Kv2.1".FEBS Lett.512 (1–3):230–4.doi:10.1016/S0014-5793(02)02267-6.PMID 11852086.S2CID 83987133.
^^a ^bGutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels".Pharmacol Rev.57 (4):473–508.doi:10.1124/pr.57.4.10.PMID 16382104.S2CID 219195192.

External links

[edit]

Kv6.3+Potassium+Channel at the U.S. National Library of MedicineMedical Subject Headings (MeSH)
KCNG3+protein,+human at the U.S. National Library of MedicineMedical Subject Headings (MeSH)

Membrane transport protein:ion channels (TC 1A)

Ca²⁺:Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺:Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺:Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻:Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺:Proton channel	HVCN1
M⁺:CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺:TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+solutes):Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm:Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin

By gating mechanism

Ion channel class	Ligand-gated Light-gated Voltage-gated Stretch-activated

see alsodisorders

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