Movatterモバイル変換

[0]ホーム

Jump to content

KCNG2

Українська

Edit links

From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

KCNG2

Identifiers

Aliases

KCNG2, KCNF2, KV6.2, potassium voltage-gated channel modifier subfamily G member 2

External IDs

OMIM:605696;MGI:3694646;HomoloGene:8178;GeneCards:KCNG2;OMA:KCNG2 - orthologs

Gene location (Human)

Chr.	Chromosome 18 (human)^[1]

Band	18q23	Start	79,797,938bp^[1]
Band	18q23	End	79,900,184bp^[1]

Gene location (Mouse)

Chr.	Chromosome 18 (mouse)^[2]

Band	18\|18 E3	Start	80,337,761bp^[2]
Band	18\|18 E3	End	80,407,469bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

sural nerve

anterior cingulate cortex

secondary oocyte

nucleus accumbens

hippocampus proper

Brodmann area 9

amygdala

gastrocnemius muscle

right frontal lobe

blood

Top expressed in

interventricular septum

myocardium of ventricle

primary visual cortex

dentate gyrus of hippocampal formation granule cell

superior frontal gyrus

embryo

yolk sac

hippocampus proper

left ventricle

right kidney

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	potassium channel activity delayed rectifier potassium channel activity voltage-gated ion channel activity ion channel activity voltage-gated potassium channel activity
Cellular component	membrane voltage-gated potassium channel complex plasma membrane extracellular exosome integral component of membrane
Biological process	regulation of heart contraction regulation of insulin secretion regulation of ion transmembrane transport ion transport potassium ion transport transmembrane transport potassium ion transmembrane transport protein homooligomerization transport
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


26251


240444

Ensembl


ENSG00000178342


ENSMUSG00000059852

UniProt


Q9UJ96


n/a

RefSeq (mRNA)


NM_012283


NM_001190373

RefSeq (protein)


NP_036415


n/a

Location (UCSC)

Chr 18: 79.8 – 79.9 Mb

Chr 18: 80.34 – 80.41 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Potassium voltage-gated channel subfamily G member 2 is aprotein that in humans is encoded by theKCNG2gene.^[5]^[6] Theprotein encoded by this gene is avoltage-gated potassium channel subunit.^[5]^[6]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000178342 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000059852 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^^a ^bZhu XR, Netzer R, Bohlke K, Liu Q, Pongs O (Dec 1999). "Structural and functional characterization of Kv6.2 a new gamma-subunit of voltage-gated potassium channel".Receptors Channels.6 (5):337–50.PMID 10551266.
^^a ^bGutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels".Pharmacol Rev.57 (4):473–508.doi:10.1124/pr.57.4.10.PMID 16382104.S2CID 219195192.

External links

[edit]

Kv6.2+Potassium+Channel at the U.S. National Library of MedicineMedical Subject Headings (MeSH)
KCNB2+protein,+human at the U.S. National Library of MedicineMedical Subject Headings (MeSH)

Membrane transport protein:ion channels (TC 1A)

Ca²⁺:Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺:Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺:Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻:Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺:Proton channel	HVCN1
M⁺:CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺:TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+solutes):Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm:Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin

By gating mechanism

Ion channel class	Ligand-gated Light-gated Voltage-gated Stretch-activated

see alsodisorders

Thismembrane protein–related article is astub. You can help Wikipedia byexpanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=KCNG2&oldid=1142789260"

Categories:

Hidden categories:

[8]ページ先頭