Kv3.1 and Kv3.2 channels are prominently expressed inneurons that fire at high frequency. Kv3.2 channels are prominently expressed in brain (fast-spiking GABAergic interneurons of theneocortex,hippocampus, andcaudate nucleus; terminal fields of thalamocortical projections), and inretinal ganglion cells.[8][9][7]
Kv3.1/Kv3.2 conductance is necessary and kinetically optimized for high-frequency action potential generation.[9][10] Sometimes in heteromeric complexes with Kv3.1; important for the high-frequency firing of fast spiking GABAergic interneurons and retinal ganglion cells; and GABA release via regulation of action potential duration in presynaptic terminals.[7][8]
Kv3.2 currents in heterologous systems are highly sensitive to externaltetraethylammonium (TEA) or4-aminopyridine (4-AP) (IC50 values are 0.1 mM for both of the drugs).[7][9] This can be useful in identifying native channels.[9]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Haas M, Ward DC, Lee J, Roses AD, Clarke V, D'Eustachio P, Lau D, Vega-Saenz de Miera E, Rudy B (Mar 1994). "Localization of Shaw-related K+ channel genes on mouse and human chromosomes".Mamm Genome.4 (12):711–5.doi:10.1007/BF00357794.PMID8111118.S2CID24121259.
^Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels".Pharmacol Rev.57 (4):473–508.doi:10.1124/pr.57.4.10.PMID16382104.S2CID219195192.
^abcdGutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stühmer W, Wang X (December 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels".Pharmacol. Rev.57 (4):473–508.doi:10.1124/pr.57.4.10.PMID16382104.S2CID219195192.
