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KCNB2

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

KCNB2

Identifiers

Aliases

KCNB2, KV2.2, potassium voltage-gated channel subfamily B member 2

External IDs

OMIM:607738;MGI:99632;HomoloGene:31263;GeneCards:KCNB2;OMA:KCNB2 - orthologs

Gene location (Human)

Chr.	Chromosome 8 (human)^[1]

Band	8q21.11	Start	72,537,225bp^[1]
Band	8q21.11	End	72,938,349bp^[1]

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)^[2]

Band	1 A3\|1 4.5 cM	Start	15,357,478bp^[2]
Band	1 A3\|1 4.5 cM	End	15,793,974bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

buccal mucosa cell

testicle

islet of Langerhans

ganglionic eminence

prefrontal cortex

Brodmann area 23

ventricular zone

dorsolateral prefrontal cortex

Brodmann area 9

entorhinal cortex

Top expressed in

olfactory bulb

dentate gyrus of hippocampal formation granule cell

ganglionic eminence

neural tube

mesencephalon

hippocampus proper

ganglion of neuraxis

secondary oocyte

Cortex of frontal lobe

primary visual cortex

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	potassium channel activity delayed rectifier potassium channel activity voltage-gated ion channel activity ion channel activity protein heterodimerization activity voltage-gated potassium channel activity
Cellular component	perikaryon cell projection membrane voltage-gated potassium channel complex plasma membrane neuronal cell body membrane dendrite integral component of membrane soma
Biological process	regulation of smooth muscle contraction regulation of ion transmembrane transport ion transport potassium ion transport transmembrane transport protein homooligomerization potassium ion transmembrane transport protein localization to plasma membrane
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


9312


98741

Ensembl


ENSG00000182674


ENSMUSG00000092083

UniProt


Q92953


A6H8H5

RefSeq (mRNA)


NM_004770


NM_001033195 NM_001098528

RefSeq (protein)


NP_004761


NP_001091998

Location (UCSC)

Chr 8: 72.54 – 72.94 Mb

Chr 1: 15.36 – 15.79 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Potassium voltage-gated channel subfamily B member 2 is aprotein that in humans is encoded by theKCNB2gene.^[5]^[6] Theprotein encoded by this gene is avoltage-gated potassium channel subunit.^[5]^[6]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000182674 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000092083 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^^a ^bSchmalz F, Kinsella J, Koh SD, Vogalis F, Schneider A, Flynn ER, et al. (May 1998). "Molecular identification of a component of delayed rectifier current in gastrointestinal smooth muscles".The American Journal of Physiology.274 (5):G901 –G911.doi:10.1152/ajpgi.1998.274.5.G901.PMID 9612272.
^^a ^bGutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, et al. (December 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels".Pharmacological Reviews.57 (4):473–508.doi:10.1124/pr.57.4.10.PMID 16382104.S2CID 219195192.

External links

[edit]

Kv2.2+Potassium+Channel at the U.S. National Library of MedicineMedical Subject Headings (MeSH)
KCNB2+protein,+human at the U.S. National Library of MedicineMedical Subject Headings (MeSH)

Membrane transport protein:ion channels (TC 1A)

Ca²⁺:Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺:Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺:Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻:Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺:Proton channel	HVCN1
M⁺:CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺:TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+solutes):Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm:Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin

By gating mechanism

Ion channel class	Ligand-gated Light-gated Voltage-gated Stretch-activated

see alsodisorders

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