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KCNAB3

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

KCNAB3

Identifiers

Aliases

KCNAB3, AKR6A9, KCNA3.1B, KCNA3B, KV-BETA-3, potassium voltage-gated channel subfamily A regulatory beta subunit 3

External IDs

OMIM:604111;MGI:1336208;HomoloGene:55844;GeneCards:KCNAB3;OMA:KCNAB3 - orthologs

Gene location (Human)

Chr.	Chromosome 17 (human)^[1]

Band	17p13.1	Start	7,921,859bp^[1]
Band	17p13.1	End	7,929,856bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	11\|11 B3	Start	69,217,084bp^[2]
Band	11\|11 B3	End	69,223,868bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right hemisphere of cerebellum

body of uterus

ventricular zone

right frontal lobe

ganglionic eminence

anterior cingulate cortex

left uterine tube

granulocyte

Brodmann area 9

prefrontal cortex

Top expressed in

inferior colliculi

lumbar subsegment of spinal cord

primary visual cortex

superior frontal gyrus

cerebellar cortex

neural layer of retina

medial vestibular nucleus

medial geniculate nucleus

deep cerebellar nuclei

lateral geniculate nucleus

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	voltage-gated potassium channel activity potassium channel regulator activity voltage-gated ion channel activity
Cellular component	cytoplasm integral component of membrane plasma membrane
Biological process	potassium ion transport regulation of ion transmembrane transport ion transport potassium ion transmembrane transport ion transmembrane transport
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


9196


16499

Ensembl


ENSG00000170049


ENSMUSG00000018470

UniProt


O43448


P97382

RefSeq (mRNA)


NM_004732


NM_010599

RefSeq (protein)


NP_004723


n/a

Location (UCSC)

Chr 17: 7.92 – 7.93 Mb

Chr 11: 69.22 – 69.22 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Voltage-gated potassium channel subunit beta-3 is aprotein that in humans is encoded by theKCNAB3gene.^[5] Theprotein encoded by this gene is avoltage-gated potassium channel beta subunit.^[5]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000170049 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000018470 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^^a ^bLeicher T, Bahring R, Isbrandt D, Pongs O (Feb 1999)."Coexpression of the KCNA3B gene product with Kv1.5 leads to a novel A-type potassium channel".J Biol Chem.273 (52):35095–101.doi:10.1074/jbc.273.52.35095.PMID 9857044.

External links

[edit]

KCNAB3+protein,+human at the U.S. National Library of MedicineMedical Subject Headings (MeSH)

Membrane transport protein:ion channels (TC 1A)

Ca²⁺:Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺:Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺:Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻:Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺:Proton channel	HVCN1
M⁺:CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺:TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+solutes):Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm:Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin

By gating mechanism

Ion channel class	Ligand-gated Light-gated Voltage-gated Stretch-activated

see alsodisorders

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