Duran spent his first professional season with theLowell Spinners andGreenville Drive, batting a combined .357 during 2018.[5][6] He started the 2019 season with theHigh-ASalem Red Sox,[7][8][9] and was promoted to the Double-APortland Sea Dogs on June 3.[10] In mid-June, Duran was added to the top 100 prospects list ofBaseball America, at number 99.[11] Duran was named to the 2019All-Star Futures Game,[12] going 1-for-2 after entering the game in the sixth inning.[13] In mid-September, Duran was named the High-A (Class A-Advanced) player of the year byBaseball America,[14] and was named the Red Sox' minor league baserunner of the year.[15] Overall during 2019 with both Salem and Portland, Duran batted .303 with five home runs and 38 RBIs in 132 games.[16]
Duran was invited to spring training by the Red Sox in 2020.[17] He did not play that season, due to cancellation of the minor league season. In November 2020, Duran was ranked byBaseball America as the Red Sox' number five prospect.[18] During the 2020–21Puerto Rican Winter League season, he was named MVP of the final series, helpingCriollos de Caguas to the championship.[19]
The Red Sox invited Duran to their spring training for the second consecutive season in 2021;[20] he subsequently started the season with theTriple-AWorcester Red Sox. On July 16, he was selected to Boston's40-man roster.[21][22] He made his MLB debut the following day, starting in center field against theNew York Yankees. In his first at-bat, he collected a hit off ofGerrit Cole and came around to score two batters later.[23] He hit his first major-league home run on July 19 againstRoss Stripling of theToronto Blue Jays.[24] Duran was placed on the COVID-19 relatedinjured list on August 6, and returned to the lineup two days later.[25][26] On August 24, Duran was optioned back to Triple-A, having batted .221 with 33 strikeouts in 89plate appearances with Boston.[27] He was recalled to Boston two days later, whenHunter Renfroe was placed on the bereavement list.[28] On September 3, Duran was placed on the COVID-related list.[29] He was activated on September 23 and optioned to Worcester.[30] Overall with Boston during the regular season, Duran appeared in 33 games, batting .215 with two home runs and 10 RBIs.[31] He also made 60 appearances for Worcester, batting .258 with 16 home runs and 36 RBIs.[32]
Duran started the 2022 season in Triple-A with Worcester.[33] He was ranked 84th in the list of baseball's top 100 prospects byBaseball America.[34] Duran was with Boston for the game of May 6, whileKiké Hernández was on the COVID-related injured list.[35][36] He was also briefly with Boston in early June, whileJackie Bradley Jr. was on the paternity list.[37] He was again recalled in mid-June whenChristian Arroyo was placed on the COVID-related list.[38] Duran remained with Boston until being placed on therestricted list in late June when the team traveled to Toronto, due to his vaccination status.[39] On July 22, he once again fell victim to Toronto, this time in center field at Fenway Park where he lost track of a fly ball and apparently gave up on the play, resulting inRaimel Tapia of the Blue Jays scoring aninside-the-parkgrand slam; the Red Sox lost the game, 28–5, setting a Blue Jays record for the largest margin of victory.[40] Duran was optioned back to Worcester on August 27, whenTrevor Story was activated from the injured list.[41] Duran was later recalled by the Red Sox for one game in Toronto, on September 30, having been vaccinated since the June series.[42] Overall for the season, Duran played in 58 major-league games, batting .221 with 3 home runs and 17 RBIs,[31] and 68 minor-league games, batting .283 with 10 home runs and 38 RBIs.[32]
Duran was optioned to Triple-A Worcester to begin the 2023 season.[43] He was recalled to Boston on April 17, after an injury toAdam Duvall[44] Over the next several months, Duran established himself as an effective hitter (ranked fourth in MLB for doubles) and base stealer (24-for-26) at the major-league level. He became a fixture in Boston's lineup, and established himself as an everyday player. On August 22, however, he was placed on the injured list due to a toe injury.[45] On August 29, it was announced that Duran would undergo a season-ending surgery forturf toe.[46][47] Duran batted .295 with 8 home runs and 40 RBIs through 102 games in 2023, adding 24 stolen bases. At the time of his injury, his 34 doubles were seventh in MLB and fourth in the American League. On September 4, the team transferred him to the 60-day injured list.[48]
Prior to spring training, Duran was announced by managerAlex Cora as theleadoff hitter for the 2024 season.[49] He was selected to play in the2024 MLB All-Star Game, and was named theAll-Star Game MVP after hitting a home run that provided the American League with the game-winning runs.[50]
On August 11, 2024, Duran was caught on broadcast audio calling aheckler a "fuckingfaggot".[51] He issued an apology and was suspended two games by the Red Sox for using a homophobic slur. MLB then stated it would then donate the salary of his suspended games to Greater PFLAG Boston.[52][53]
In 2024, Duran led the major leagues in plate appearances with 735, at bats with 675, and doubles with 48, tied for the MLB lead with 14 triples, and posted a .285/.342/.492slash line with 111 runs, 24 home runs, and 75 RBIs.[54] He placed 8th inAmerican League MVP voting.[55]
In 2022, Duran attemptedsuicide using a rifle. In the 2025Netflix documentaryThe Clubhouse: A Year With the Red Sox, he said “I had my rifle and I had a bullet, and I pulled the trigger and the gun clicked, but nothing happened.”[59]
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