He attendedVanderbilt University to playcollege baseball.[11][12] In his college debut on February 18, 2020, Leiter pitched five no-hit innings while striking out 12, leading Vanderbilt to a 3–0 victory over theUniversity of South Alabama.[13][14][15] He was named theSoutheastern Conference (SEC) Co-Freshman of the Week following the performance.[16][17] Over 152⁄3 innings, Leiter went 2–0 with a 1.72 ERA before the college baseball season was cancelled due to theCOVID-19 pandemic.[18] As a redshirt freshman in 2021, Leiter returned as a member of Vanderbilt's starting rotation.[19] On March 20, 2021, he pitched a no-hitter in his SEC debut against South Carolina, compiling sixteen strikeouts.[20] In his next start, he pitched seven no-hit innings against Missouri.[21] He was named the SEC Newcomer of the Year alongside being selected a consensusfirst-team All-American.[22][23] He helped lead Vanderbilt to the2021 College World Series finals and was named to the All-Tournament team.[24] Leiter ended the 2021 season having started 18 games, in which he compiled an 11–4 record, a 2.13 ERA, and 179 strikeouts over 110 innings.[25] He was named theBaseball America 2021 Freshman of the Year.[26]
TheTexas Rangers chose Leiter with the second overall selection in the2021 Major League Baseball draft.[27][28][29] Leiter signed with Texas on July 28, 2021, receiving a $7.92 millionsigning bonus.[30][31] Leiter attended an organization draftee orientation at the Rangersspring training complex after signing, but did not appear in a professional game in 2021, instead choosing to return to Vanderbilt to continue college course work.[32]
Leiter opened the 2022 season with theFrisco RoughRiders of theDouble-ATexas League.[33] He made his professional debut on April 9, going three innings while allowing one run and striking out seven batters.[34][35] He was selected to represent the Rangers at the 2022All-Star Futures Game.[36] Over 23 games (22 starts) with Frisco, Leiter went 3–10 with a 5.54 ERA, 56 walks, and 109 strikeouts over92+2⁄3 innings.[37] He received a non-roster invitation to major league spring training in 2023,[38] and returned to Frisco to open the season.[39] Leiter once again struggled in 2023, including spending almost two months out of game action on the development list.[40] With Frisco, he went 2–6 with a 5.06 ERA and 110 strikeouts over81+1⁄3 innings.[41] He finished the 2023 season with one start for theRound Rock Express of theTriple-APacific Coast League.[42] Leiter returned to Round Rock for the beginning of the 2024 season.[43] After the season, he won thePacific Coast League Pitcher of the Year Award.[44]
On April 18, 2024, the Texas Rangers selected Leiter’s contract and promoted him to make his major league debut that day against the Detroit Tigers.[45] In his debut game, he allowed eight hits and seven earned runs with three strikeouts in3+2⁄3 innings to earn a no decision as the Rangers ultimately won against the Tigers 9–7.[46] In his first season with the Rangers, Leiter had a rocky season with a 10-10 record and 3.86 ERA but struck out 148 batters in 1512⁄3 innings.