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| Names | |
|---|---|
| Preferred IUPAC name 4-Nitrophenyl 4-[di(2H-1,3-benzodioxol-5-yl)(hydroxy)methyl]piperidine-1-carboxylate | |
| Identifiers | |
3D model (JSmol) | |
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| ChEMBL | |
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| UNII | |
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| Properties | |
| C27H24N2O9 | |
| Molar mass | 520.15 g/mol |
| Appearance | Pale yellow solid |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
JZL184 is an irreversibleinhibitor formonoacylglycerol lipase (MAGL), the primaryenzyme responsible for degrading theendocannabinoid2-arachidonoylglycerol (2-AG).[1] It displays high selectivity for MAGL over otherbrainserine hydrolases, including theanandamide-degrading enzymefatty acid amide hydrolase (FAAH), thereby making it a useful tool for studying the effects of endogenous2-AG signaling,in vivo. Administration of JZL184 to mice was reported to cause dramatic elevation of brain2-AG leading to severalcannabinoid-related behavioral effects.
 | Thiscannabinoid related article is astub. You can help Wikipedia byexpanding it. |
