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| Formula | C27H27NO |
| Molar mass | 381.519 g·mol−1 |
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JWH-370 ([5-(2-methylphenyl)-1-pentylpyrrol-3-yl]-naphthalen-1-ylmethanone) is asynthetic cannabinoid from the naphthoylpyrrole family which acts as an agonist of theCB1 (Ki = 5.6 ± 0.4nM) andCB2 (Ki = 4.0 ± 0.5nM) receptors, with a slight selectivity for the CB2 receptor. JWH-370 was first synthesized in 2006 byJohn W. Huffman and colleagues to examine the nature of ligand binding to theCB1 receptor.[1]
In the United States JWH-370 is not federally scheduled, although some states have passed legislation banning the sale, possession, and manufacture of JWH-370.[2][3][4][5]
In Canada, JWH-370 and other naphthoylpyrrole-based cannabinoids are Schedule II controlled substances under theControlled Drugs and Substances Act.[citation needed]
In the United Kingdom, JWH-370 and other naphthoylpyrrole-based cannabinoids are considered Class B drugs under theMisuse of Drugs Act 1971.[citation needed]
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