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| Formula | C25H25NO2 |
| Molar mass | 371.480 g·mol−1 |
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JWH-164 is a syntheticcannabinoid receptoragonist from the naphthoylindole family. It has approximately equal affinity for theCB1 andCB2 receptors, with aKi of 6.6 nM at CB1 and 6.9 nM at CB2. JWH-164 is apositional isomer of the related compoundJWH-081, but with amethoxy group at the 7-position of thenaphthyl ring, rather than the 4-position as in JWH-081. Its potency is intermediate between that of JWH-081 and its ring unsubstituted derivativeJWH-018, demonstrating that substitution of the naphthyl 7-position can also result in increased cannabinoid receptor binding affinity.[1][2]
In the United States, all CB1 all receptor agonists of the 3-(1-naphthoyl)indole class, including JWH-164, areSchedule I Controlled Substances.[3]
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