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| Chemical and physical data | |
| Formula | C24H36O2 |
| Molar mass | 356.550 g·mol−1 |
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JWH-138 (THC-Octyl,Δ8-THC-C8) is a syntheticcannabinoid first synthesized by Roger Adams and studied heavily byJohn W. Huffman, with aKi of 8.5nM at the CB1cannabinoid receptor.[1] THC-Octyl and its hydrogenated analog HHC-Octyl was synthesized and studied by Roger Adams as early as 1942.[2]
The Δ3/Δ6a(10a) isomer was synthesised in 1941, but was found to be slightly less active thanΔ3-THC itself.[3] The alternate isomer Δ9-THC-C8 has also been synthesised,[4] and both the Δ8 and Δ9 isomers are included within the definition of an "intoxicating cannabinoid" in Colorado under the nametetrahydrocannabioctyl,[5] but it is unclear if it has been identified as a natural product. Tetrahydrocannabioctyl is sometimes referred to as THC-Octyl or THC-O, which may cause confusion withTHC-O-acetate which is commonly known as THC-O on packaging forgrey marketvaping liquids sold for use in humans. Both Δ8 and Δ9 (C8)-THC have been sold asdesigner drugs, first identified in Denmark in August 2024.[6]
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