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JWH-030

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
JWH-030
Legal status
Legal status
Identifiers
  • Naphthalen-1-yl-(1-pentylpyrrol-3-yl)methanone
CAS Number
PubChemCID
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UNII
ChEMBL
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Chemical and physical data
FormulaC20H21NO
Molar mass291.394 g·mol−1
3D model (JSmol)
  • CCCCCn3cc(cc3)C(=O)c1cccc2ccccc12
  • InChI=1S/C20H21NO/c1-2-3-6-13-21-14-12-17(15-21)20(22)19-11-7-9-16-8-4-5-10-18(16)19/h4-5,7-12,14-15H,2-3,6,13H2,1H3
  • Key:VPBJQDBKZSHCPC-UHFFFAOYSA-N
  (verify)

JWH-030 is a research chemical which is acannabinoid receptoragonist.[2] It hasanalgesic effects and is used in scientific research.[3] It is a partial agonist atCB1 receptors, with aKi of 87 nM, making it roughly half the potency ofTHC.[4] It was discovered and named afterJohn W. Huffman.

In the United States, CB1 receptor agonists of the 3-(1-naphthoyl)pyrrole class such as JWH-030 areSchedule I Controlled Substances.[5]

See also

[edit]

References

[edit]
  1. ^"Stoffe gem. Anlagen zum BtMG". Retrieved2024-11-23.
  2. ^Lainton JA, Huffman JW, Martin BR, Compton DR (February 1995). "1-Alkyl-3-(1-naphthoyl) pyrroles: A new class of cannabinoid".Tetrahedron Letters.36 (9):1401–4.doi:10.1016/0040-4039(95)00016-6.
  3. ^Pertwee RG, Griffin G, Lainton JA, Huffman JW (September 1995). "Pharmacological characterization of three novel cannabinoid receptor agonists in the mouse isolated vas deferens".European Journal of Pharmacology.284 (3):241–7.doi:10.1016/0014-2999(95)00318-f.PMID 8666005.
  4. ^Griffin G, Atkinson PJ, Showalter VM, Martin BR, Abood ME (May 1998). "Evaluation of cannabinoid receptor agonists and antagonists using the guanosine-5'-O-(3-[35S]thio)-triphosphate binding assay in rat cerebellar membranes".The Journal of Pharmacology and Experimental Therapeutics.285 (2):553–60.PMID 9580597.
  5. ^21 U.S.C. § 812:Schedules of controlled substances
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