JWH-015 is a chemical from thenaphthoylindole family that acts as a subtype-selectivecannabinoidagonist. Its affinity forCB2 receptors is 13.8 nM, while its affinity forCB1 is 383 nM, meaning that it binds almost 28 times more strongly to CB2 than to CB1.[1] However, it still displays some CB1 activity, and in some model systems can be very potent and efficacious at activating CB1 receptors,[2] and therefore it is not as selective as newer drugs such asJWH-133.[3] It has been shown to possessimmunomodulatory effects,[4][5] and CB2 agonists may be useful in the treatment of pain and inflammation.[6][7] It was discovered and named afterJohn W. Huffman.
^Aung MM, Griffin G, Huffman JW, Wu M, Keel C, Yang B, et al. (August 2000). "Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2)receptor binding".Drug and Alcohol Dependence.60 (2):133–140.doi:10.1016/S0376-8716(99)00152-0.PMID10940540.
^Marriott KS, Huffman JW (2008). "Recent advances in the development of selective ligands for the cannabinoid CB(2) receptor".Current Topics in Medicinal Chemistry.8 (3):187–204.doi:10.2174/156802608783498014.PMID18289088.
^Ghosh S, Preet A, Groopman JE, Ganju RK (July 2006). "Cannabinoid receptor CB2 modulates the CXCL12/CXCR4-mediated chemotaxis of T lymphocytes".Molecular Immunology.43 (14):2169–2179.doi:10.1016/j.molimm.2006.01.005.PMID16503355.
^Montecucco F, Burger F, Mach F, Steffens S (March 2008). "CB2 cannabinoid receptor agonist JWH-015 modulates human monocyte migration through defined intracellular signaling pathways".American Journal of Physiology. Heart and Circulatory Physiology.294 (3):H1145 –H1155.doi:10.1152/ajpheart.01328.2007.PMID18178718.S2CID5896815.
^Balter MB, Uhlenhuth EH (1992). "Prescribing and use of benzodiazepines: an epidemiologic perspective".Journal of Psychoactive Drugs.24 (1):63–64.doi:10.1080/02791072.1992.10471620.PMID1352348.
^Zhang Q, Ma P, Cole RB, Wang G (November 2006). "Identification of in vitro metabolites of JWH-015, an aminoalkylindole agonist for the peripheral cannabinoid receptor (CB2) by HPLC-MS/MS".Analytical and Bioanalytical Chemistry.386 (5):1345–1355.doi:10.1007/s00216-006-0717-6.PMID16955257.S2CID9116612.
^Zhang Q, Ma P, Iszard M, Cole RB, Wang W, Wang G (October 2002). "In vitro metabolism of R(+)-[2,3-dihydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo [1,2,3-de]1,4-benzoxazinyl]-(1-naphthalenyl) methanone mesylate, a cannabinoid receptor agonist".Drug Metabolism and Disposition.30 (10):1077–1086.doi:10.1124/dmd.30.10.1077.PMID12228183.S2CID10848076.
^"关于印发《非药用类麻醉药品和精神药品列管办法》的通知" [Notice on Issuing the Measures for the Listing and Control of Non-Medicinal Narcotic Drugs and Psychotropic Substances] (in Chinese). China Food and Drug Administration. 27 September 2015. Archived fromthe original on 1 October 2015. Retrieved1 October 2015.
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