He became the eighth chancellor of UCSF in 1998. He oversaw one of UCSF's major transition and growth periods, including the expanding Mission Bay development and philanthropic support recruitment. During his tenure, he unveiled the first comprehensive, campus-wide, strategic plan to promote diversity and foster a supportive work environment. During this time, UCSF also adopted a new mission:advancing health worldwide™.[9]
Much of this work was conducted jointly with Harold Varmus in a notably long scientific partnership. Their best-known accomplishment[10] was the identification of a cellular gene (c-src) that gave rise to the v-src oncogene of Rous Sarcoma Virus, a cancer-causing virus first isolated from a chicken sarcoma byPeyton Rous in 1910. Their discovery triggered the identification of many other cellular proto-oncogenes—progenitors of viral oncogenes and targets for mutations that drive human cancers.
Bishop is best known for his Nobel-winning work onretroviraloncogenes. Working withHarold E. Varmus in the 1980s, he discovered the first human oncogene,c-Src. Their findings allowed the understanding of how malignanttumors are formed from changes to the normalgenes of acell. These changes can be produced by viruses, by radiation, or by exposure to some chemicals.[4][11][12][13]
The University of California, San Francisco Archives and Special Collections houses a collection of J. Michael Bishop papers, including his laboratory research notebooks, writings, photographs, and other material.[19]