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Deterenol

From Wikipedia, the free encyclopedia
(Redirected fromIsopropyloctopamine)
Chemical compound
Pharmaceutical compound
Deterenol
Clinical data
Trade namesBetafrine
Other namesIsopropylnorsynephrine, Isopropyloctopamine
Identifiers
  • 4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenol
CAS Number
PubChemCID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC11H17NO2
Molar mass195.262 g·mol−1
3D model (JSmol)
  • CC(C)NCC(C1=CC=C(C=C1)O)O
  • InChI=1S/C11H17NO2/c1-8(2)12-7-11(14)9-3-5-10(13)6-4-9/h3-6,8,11-14H,7H2,1-2H3
  • Key:MPCPSVWSWKWJLO-UHFFFAOYSA-N

Deterenol (also known asIsopropylnorsynephrine andIsopropyloctopamine; trade nameBetaphrine) is astimulant drug which acts as abeta agonist. It has been found as an ingredient ofdietary supplement products, but is banned in most countries due to risk ofcardiac arrest.[1][2][3][4][5]

See also

[edit]

References

[edit]
  1. ^Anderson WG (June 1983). "The sympathomimetic activity of N-isopropyloctopamine in vitro".The Journal of Pharmacology and Experimental Therapeutics.225 (3):553–8.doi:10.1016/S0022-3565(25)33627-X.PMID 6306210.
  2. ^Mercader J, Wanecq E, Chen J, Carpéné C (September 2011). "Isopropylnorsynephrine is a stronger lipolytic agent in human adipocytes than synephrine and other amines present in Citrus aurantium".Journal of Physiology and Biochemistry.67 (3):443–52.doi:10.1007/s13105-011-0078-2.PMID 21336650.S2CID 22449550.
  3. ^Venhuis B, Keizers P, van Riel A, de Kaste D (June 2014). "A cocktail of synthetic stimulants found in a dietary supplement associated with serious adverse events".Drug Testing and Analysis.6 (6):578–81.doi:10.1002/dta.1664.PMID 24802503.
  4. ^Zhao J, Wang M, Avula B, Khan IA (March 2018)."Detection and quantification of phenethylamines in sports dietary supplements by NMR approach".Journal of Pharmaceutical and Biomedical Analysis.151:347–355.doi:10.1016/j.jpba.2018.01.025.PMID 29413984.S2CID 46837518.
  5. ^Cohen PA, Travis JC, Vanhee C, Ohana D, Venhuis BJ (March 2021)."Nine prohibited stimulants found in sports and weight loss supplements: deterenol, phenpromethamine (Vonedrine), oxilofrine, octodrine, beta-methylphenylethylamine (BMPEA), 1,3-dimethylamylamine (1,3-DMAA), 1,4-dimethylamylamine (1,4-DMAA), 1,3-dimethylbutylamine (1,3-DMBA) and higenamine".Clinical Toxicology.59 (11):975–981.doi:10.1080/15563650.2021.1894333.PMID 33755516.
α1
Agonists
Antagonists
α2
Agonists
Antagonists
β
Agonists
Antagonists


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